Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy

St. Louis University1 site in 1 country6 target enrollmentFebruary 17, 2017

ConditionsAcute Kidney Injury End-stage Renal Disease

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Acute Kidney Injury
Sponsor: St. Louis University
Enrollment: 6
Locations: 1
Primary Endpoint: Blood Pressure Change
Status: Terminated
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.

Registry

clinicaltrials.gov

Start Date

February 17, 2017

End Date

June 30, 2018

Last Updated

6 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

St. Louis University

Responsible Party

Principal Investigator

Zafar Jamkhana, MD

Associate Professor

St. Louis University

Eligibility Criteria

Inclusion Criteria

•Age 18-89
•Acute renal failure or end-stage renal disease necessitating CRRT
•Admitted to the MICU service
•If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
•If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
•If on IV fluids, stable dose of crystalloids \<= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
•Mean arterial pressure (MAP) \>= 65
•Arterial catheter present for continuous blood pressure monitoring
•CRRT duration of 48 hours or less using NxStage System One dialysis system
•successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability

Exclusion Criteria

•listed for organ transplant
•atrial fibrillation, other irregular heart rhythm, unstable arrhythmia
•need for more than one intravenous vasopressor agent
•intravenous vasopressor/inotropic agent other than norepinephrine (ie dobutamine, dopamine, vasopressin, epinephrine)
•therapeutic anticoagulation being administered
•known acute myocardial infarction as defined by elevated troponin along with a documented clinical diagnosis during current hospitalization
•known acute stroke, intracerebral hemorrhage, intracranial mass effect, or elevated intracranial pressure within the last 30 days.
•dialysis catheter malfunction and unable to maintain target blood flow rate
•fluid removal (ultrafiltration) rate \> 100mL/hour