Hemodynamic Effects of Blood Flow Variation in Continuous Renal Replacement Therapy
Not Applicable
Terminated
- Conditions
- End-stage Renal DiseaseAcute Kidney Injury
- Registration Number
- NCT03078504
- Lead Sponsor
- St. Louis University
- Brief Summary
Purpose of this study is to evaluate the short-term hemodynamic effects of changes in blood flow rates in critically ill patients receiving continuous renal replacement therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 6
Inclusion Criteria
- Age 18-89
- Acute renal failure or end-stage renal disease necessitating CRRT
- Admitted to the MICU service
- If on vasopressor/inotropic agent, norepinephrine as only intravenous pressor
- If on vasopressor/inotropic agent, at stable pressor dose for at least four hours
- If on IV fluids, stable dose of crystalloids <= 100cc/hour and is not receiving colloids for 4 hours or more prior to initiation of CRRT
- Mean arterial pressure (MAP) >= 65
- Arterial catheter present for continuous blood pressure monitoring
- CRRT duration of 48 hours or less using NxStage System One dialysis system
- successfully tolerated CRRT for at least 4 hours without clotting or hemodynamic instability
- no other procedures, blood products transfusion, or additional medication administration are anticipated during the study period
Exclusion Criteria
- listed for organ transplant
- atrial fibrillation, other irregular heart rhythm, unstable arrhythmia
- need for more than one intravenous vasopressor agent
- intravenous vasopressor/inotropic agent other than norepinephrine (ie dobutamine, dopamine, vasopressin, epinephrine)
- therapeutic anticoagulation being administered
- known acute myocardial infarction as defined by elevated troponin along with a documented clinical diagnosis during current hospitalization
- known acute stroke, intracerebral hemorrhage, intracranial mass effect, or elevated intracranial pressure within the last 30 days.
- dialysis catheter malfunction and unable to maintain target blood flow rate
- fluid removal (ultrafiltration) rate > 100mL/hour
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Blood Pressure Change 10 minutes Change in mean arterial pressure from period 1 to period 2
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
Saint Louis University🇺🇸Saint Louis, Missouri, United States