The comparison of Immune response to the 4th dose booster with mRNA-1273 COVID-19 vaccine in individuals who had received 2 doses of CoronaVac and booster with ChAdOx-1 or BNT162b2 COVID-19 vaccine
Recruiting
- Conditions
- Booster vaccination with mRNA 1273 COVID vaccine in individuals who had received 2 doses of CoronaVac and booster with BNT162b2 or ChAdOx-1 COVID vaccine.mRNA 1273 , booster, covid 19 vaccine, immunogenicity
- Registration Number
- TCTR20220205002
- Lead Sponsor
- Thammasat University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
A healthy adults aged 18 years and older who had received 2 doses of CoronaVac and booster with BNT162b2 or ChAdOx-1 COVID vaccine.
Exclusion Criteria
- Acute fever with body temperature above 38 degree Celsius on the day of vaccination.
- History of COVID-19 infection
- Get another vaccination no more than 2 weeks before enrollment.
- pregnant with a gestational age of less than 12 weeks
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Immunogenicity 14 days after complete vaccination Anti-S-RBD antibody level ,Reactogenicity 7 days after vaccination Diary card
- Secondary Outcome Measures
Name Time Method Persistent of immune response 6 months after complete vaccination Anti-S-RBD antibody level and ELISpot,Immunogenicity 6 months after complete vaccination Anti-S-RBD antibody level and ELISpot