KCT0007591招募中未知
An open-label, phase 4trial of sotorasib in KRAS G12C-mutant non-small-cell lung cancer(NSCLC) patients and a translational study to find acquired resistance mechanism to sotorasib
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 37
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 19(Year) 至 o Limit（—）
- 性别
- All
入选标准
- •1.Subject or subject’s legally acceptable representative has provided informed consent prior to initiation of any study specific activities/procedures.
- •2.Age ? 19 years of age
- •3.Histologically or pathologically documented, locally-advanced and unresectable or metastatic NSCLC.
- •4.have documentation of KRAS p.G12C mutation confirmed by local testing through the current protocol or have documentation of KRAS p.G12C mutation prior to enrollment.
- •5.Subjects will have received and progressed or experienced disease recurrence on or after receiving at least 1 prior systemic therapy for locally advanced and unresectable or metastatic disease.
- •6.Adjuvant therapy will count as a line of therapy if the subject progressed on or within 6 months of adjuvant therapy administration.
- •7.In locally advanced and unresectable NSCLC, disease progression on or within 6 months of end of prior curatively intended multimodal therapy will count as a line of therapy. If chemoradiation is followed by planned systemic therapy without documented progression between chemoradiation and systemic therapy, the entire treatment course counts as one line of therapy.
- •8.Maintenance therapy following platinum doublet-based chemotherapy is not considered as a separate line of therapy.
- •9.Subjects must have archived tumor tissue samples (formalin fixed, paraffin embedded [FFPE] sample [FFPE of excisional, core needle, or fine needle aspirate] collected within 5 years) or be willing to undergo pre-treatment b iopsy (excisional, core needle, or fine needle aspirate) for tissue prior to enrollment.
- •10.Measurable disease per RECIST v1.1 criteria.
- •11.ECOG Performance Status of ? 1
- •12.Adequate hematologic laboratory assessments, defined as the following within 28 days prior to start of study therapy:
- •a)Absolute neutrophil count (ANC) ? 1500 cells/?l (without granulocyte colony-stimulating factor support within 10 days of laboratory test used to determine eligibility)
- •b)Hemoglobin ? 9.0 g/dL (without transfusion within 2 weeks of laboratory test used to determine eligibility)
- •c)Platelet count ? 100,000/?l (without transfusion within 2 weeks of laboratory test used to determine eligibility)
- •13.Life expectancy of > 3 months, in the opinion of the investigator
- •14.Adequate liver function, defined as the following:
- •a)Aspartate aminotransferase (AST) and, alanine aminotransferase (ALT) ? 2.5 times the upper limit of normal (ULN), except if alkaline phosphatase > 2.5 times the ULN, then AST and/or ALT must be ? 1.5 times the ULN
- •b)Serum bilirubin ? 1.0 x ULN
- •c)International normalized ratio (INR) and activated partial thromboplastin time ? 1.5 x ULN
- •d)Serum creatinine ? 1.5 x ULN OR creatinine clearance ? 60 mL/min. Cockcroft- Gault formula will be used for creatinine clearance calculation. Twenty-four hour urine collection is not required but is allowed.
- •15. QTc ? 470 msec in females and ? 450 msec in males (based on average of screening triplicates)
- •-Subject should perform 12-lead ECG 3times within 15minutes at intervals of 2-5 minutes after resting in the sitting position for 5minutes.
- •16. Ability to take oral medications and willing to record daily adherence to investigational product
排除标准
- •1.Previously identified driver mutation (according to local standard of care or guidelines) other than KRAS p.G12C for which an approved therapy is available (including EGFR, ALK, ROS1, BRAF etc)
- •2.Active brain metastases. Subjects who have had brain metastases resected or have received whole brain radiation therapy ending at least 4 weeks (or stereotactic radiosurgery ending at least 2 weeks) prior to study day 1 are eligible if they meet all of the following criteria: a) residual neurological symptoms grade ? 2; b) on stable doses of dexamethasone or equivalent for at least 2 weeks, if applicable; and c) follow-up MRI performed within 30 days prior to enrollment shows no progression or new lesions appearing.
- •3.Leptomeningeal disease.
- •4.Exclusion of hepatitis infection based on the following results and/or criteria:
- •a)Positive hepatitis B surface antigen (HepBsAg) (indicative of chronic Hepatitis B or recent acute hepatitis B)
- •b) Subjects with a prior history of HBV proven to be positive for hepatitis B core antibody
- •1) Surface antigen (HBsAg) is negative
- •2) It is suitable if the HBV deoxyribonucleic acid (DNA; viral load) is less than the lower limit of quantitation according to the local test. Subjects positive for HBsAg due to recent vaccination are eligible if their HBV DNA (viral load) is below the lower limit of quantitation according to local testing.
- •5.Malignancy other than NSCLC within 2 years prior to first dose of drug, with the exception of those with a negligible risk of metastases or death and treated with expected curative outcome (such as adequately treated carcinoma in situ of the cervix, basal cell carcinoma, cutaneous squamous cell carcinoma, localized prostate cancer treated with curative intent, or ductal carcinoma in situ treated surgically with curative intent).
- •6.Significant gastrointestinal disorder that results in significant malabsorption, requirement for intravenous alimentation, or inability to take oral medication.
- •7.Significant cardiovascular disease, myocardial infarction within 6 months prior to study day 1, unstable arrhythmias or unstable angina.
- •8.Severe infections within 4 weeks prior to first dose of drug including, but not limited to hospitalization for complications of infection, bacteremia or severe pneumonia.
- •9.Subjects participating in other clinical trials are excluded.
- •10. Previous treatment with sotorasib or other KRAS G12C inhibitor
- •11. Female subjects of childbearing potential unwilling to use 1 highly effective method of contraception during treatment and for an additional 7 days after the last dose of sotorasib.
- •12.Female subjects of childbearing potential with a positive pregnancy test assessed at Screening or day 1 by a serum pregnancy test and/or urine pregnancy test.
- •13.Male subjects with a female partner of childbearing potential who are unwilling to practice sexual abstinence (refrain from heterosexual intercourse) or use contraception during treatment and for an additional 7 days (sotorasib).
- •14.Subject likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures (eg, Clinical Outcome Assessments) to the best of the subject and investigator’s knowledge.
- •15.History or evidence of any other clinically significant disorder, condition or disease (with the exception of those outlined above) that, in the opinion of the investigator or Amgen physician, if consulted, would
研究者
相似试验
招募中
2 期
SHERLOCK: Phase 2 trial of sotorasib in combination with carboplatin-pemetrexed and bevacizumab-biosimilar as first line treatment for advanced non-squamous non-small cell lung cancerwith KRAS G12C mutatioACTRN12622000973718The University of Sydney52
已完成
1 期
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)KRAS p.G12C Mutant Advanced Solid TumorsNCT03600883Amgen713
撤回
2 期
Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLCNon-Small Cell Lung CancerNCT05400577Fox Chase Cancer Center
招募中
1 期
Sotorasib in advanced KRAS G12C-mutated non-small cell lung cancer patients with comorbidities (SOLUCOM)KRAS G12C-mutated non-small cell lung cancerMedDRA version: 20.0Level: LLTClassification code: 10025055Term: Lung cancer non-small cell stage IV Class: 10029104MedDRA version: 22.0Level: LLTClassification code: 10069759Term: KRAS mutation Class: 10018065MedDRA version: 20.0Level: LLTClassification code: 10025052Term: Lung cancer non-small cell stage III Class: 10029104CTIS2023-503174-20-00Vestre Viken HF100
进行中（未招募）
1 期
A research study to evaluate the activity of Sotorasib for the treatment of patients with non-operable non-small cell lung cancer with a KRAS mutatioCTIS2024-511268-10-00Fundacion GECP43