Effects of Muscle Energy Technique in Knee Osteoarthritis Patients
- Conditions
- Knee Osteoarthritis
- Interventions
- Other: CONVENTIONAL PHYSICAL THERAPYOther: MUSCLE ENERGY TECHNIQUE
- Registration Number
- NCT05349565
- Lead Sponsor
- Riphah International University
- Brief Summary
To determine the effectiveness of muscle energy technique along conventional physical therapy after mesenchymal stem cell transplantation in knee Osteoarthritis patients regarding Pain, range of motion, functional disability and quality of life.
- Detailed Description
Mesenchymal stem cells (MSCs) replacement is a regenerative therapeutic procedures for the early treatment of cartilaginous defects in knee osteoarthritis. MSCs may improve symptoms and function in osteoarthritic joints but also decrease inflammation and induce cartilage healing by differentiating into chondrocytes, osteoblasts and indicating appropriate extracellular matrix proteins (i.e. collagen I and II) through the secretion of cytokines, chemokines, and growth factors from MSCs.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
- Both male and female
- Age > 40 years
- Knee osteoarthritis patients undergone mesenchymal stem cell transplantation.
- History of recent or past septic arthritis
- Patients with neurological deficit
- Uncontrolled diabetes
- Malignancy
- Vascular insufficiency
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CONVENTIONAL PHYSICAL THERAPY CONVENTIONAL PHYSICAL THERAPY TENS , Open chain knee flexion and extension, Calf stretch , Quad set MUSCLE ENERGY TECHNIQUE MUSCLE ENERGY TECHNIQUE MET ( isometric contraction with 6-10 sec )
- Primary Outcome Measures
Name Time Method Numeric Pain Rating Scale (NPRS) NPRS used to measure changes from baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session. The Numeric Pain Rating Scale (NPRS) is the simplest and most commonly used numeric scale to rate the pain from 0 (no pain) to 10 (worst pain).
- Secondary Outcome Measures
Name Time Method Goniometer (range of motion) baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session. Knee flexion and extension ranges were taken using goniometer to measure changes in ROM.
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) WOMAC index used to measure changes from baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is widely used to measure symptoms and physical disability, originally developed for people with OA of the hip or knee. It evaluates three dimensions: pain, stiffness, and physical function with 5, 2, and 17 questions. The scores for each subscale are summed up, with a possible score range of 0-20 for Pain, 0-8 for Stiffness, and 0-68 for Physical Function, a total of 96, 0 (no symptoms/no limitation) and 96 (maximal symptoms/maximal limitation).
SF-12 (quality of life) SF-12 used to measure changes from baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session. The SF-12 focuses on patient-based assessments of physical and mental health. Scores range from 0 to 100, with higher scores indicating better physical and mental health functioning. A score of 50 or less on the PCS-12 has been recommended as a cut-off to determine a physical condition; while a score of 42 or less on the MCS-12 may be indicative of 'clinical depression.
Trial Locations
- Locations (1)
Institute of Regenerative medicine
🇵🇰Islamabad, Pakistan