Effects of Muscle Energy Technique Along Conventional Physical Therapy After Mesenchymal Stem Cell Transplantation in Knee Osteoarthritis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Knee Osteoarthritis
- Sponsor
- Riphah International University
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- Numeric Pain Rating Scale (NPRS)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
To determine the effectiveness of muscle energy technique along conventional physical therapy after mesenchymal stem cell transplantation in knee Osteoarthritis patients regarding Pain, range of motion, functional disability and quality of life.
Detailed Description
Mesenchymal stem cells (MSCs) replacement is a regenerative therapeutic procedures for the early treatment of cartilaginous defects in knee osteoarthritis. MSCs may improve symptoms and function in osteoarthritic joints but also decrease inflammation and induce cartilage healing by differentiating into chondrocytes, osteoblasts and indicating appropriate extracellular matrix proteins (i.e. collagen I and II) through the secretion of cytokines, chemokines, and growth factors from MSCs.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Both male and female
- •Age \> 40 years
- •Knee osteoarthritis patients undergone mesenchymal stem cell transplantation.
Exclusion Criteria
- •History of recent or past septic arthritis
- •Patients with neurological deficit
- •Uncontrolled diabetes
- •Malignancy
- •Vascular insufficiency
Outcomes
Primary Outcomes
Numeric Pain Rating Scale (NPRS)
Time Frame: NPRS used to measure changes from baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session.
The Numeric Pain Rating Scale (NPRS) is the simplest and most commonly used numeric scale to rate the pain from 0 (no pain) to 10 (worst pain).
Secondary Outcomes
- Goniometer (range of motion)(baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session.)
- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)(WOMAC index used to measure changes from baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session.)
- SF-12 (quality of life)(SF-12 used to measure changes from baseline pre and post 2 weeks physiotherapy session in knee OA patients after mesenchymal stem cell replacement and on 1 month follow up session.)