The value of biomarkers in cerebrospinal fluid in acute spinal cord injury as predictor of outcome.

Completed

• Conditions: spinal cord injury; traumatic myelopathy; 10041543

• Registration Number: NL-OMON34689
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Blunt spinal cord injury (Neurological level of injury C2-Th10)
Neurological deficit
Primarily refererred
Glasgow Coma Scale >= 10 (E4+V6)

Exclusion Criteria

penetrating spinal cord injury
normal neurologic examination
non-traumatic spinal cord injury
traumatic brain injury
pre-existent neurological disorder

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The concentrations of Neuron Specific Enolase, Glial Fibrillary Acidic<br /><br>Protein, S-100ß, Neurofilament Protein, Tau and Myelin Basic Protein in CSF in<br /><br>patients with SCI.<br /><br>2. Evaluation of the ASIA classification system and SCIM of all patients at<br /><br>different times<br /><br>3. The relation between the concentrations of Neuron Specific Enolase, Glial<br /><br>Fibrillary Acidic Protein, S-100ß, Neurofilament Protein, Tau and Myelin Basic<br /><br>Protein in CSF and the ASIA impairment scale after 12 months in SCI patients </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>is not applicable </p><br>