Analysis of Motor Skills in Subjects Aged 55 and Over: the Role of Cognitive Abilities for Planning Movement.

Recruiting

• Conditions: Mild Cognitive Disorder
• Interventions: Other: Sequence 1; Other: Sequence 2; Other: Sequence 3

• Registration Number: NCT04754906
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

Falling is an event that is more frequent and severe in older age. It can lead to a loss of autonomy and a decrease in quality of life. It is therefore important to understand this phenomenon in order to better prevent it. Among the multiple risk factors associated with falling, recent research has shown a link between the decline in cognitive abilities (i.e., the mental processes that form our knowledge, such as memory) and the risk of falling. However, the impact of this cognitive decline on motor skills is still poorly understood. The purpose of this research is to study how the changes induced by aging affect motor skills. This would make it possible to take a new look at the phenomenon of falls occurring in the elderly and, in the long term, to improve the prevention and rehabilitation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-10-06
• Study Start: 2021-01-25
• Study First Submitted QC: 2021-02-11
• Study First Posted: 2021-02-15
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-08
• Last Update Posted: 2023-12-11
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 684

Inclusion Criteria

1. Neurotypical subjects group:

   • Person aged 18 to 40 years
   • Person who has given oral consent
   • Affiliated to national health insurance
   • Right-handed person

2. Group of elderly neurotypical subjects:

   • Person over 55 years of age
   • Person who has given oral consent
   • Affiliated to national health insurance
   • No cognitive problems (MMSE score >26)
   • Right-handed person

3. Elderly mild cognitive disorder subject group:

   • Person over 55 years of age
   • Person who has given oral consent
   • Diagnosis of Mild Cognitive Disorder made by a neurologist at the Centre Mémoire Ressources et Recherche (CMRR) of the University Hospital of Dijon, following the recommendations of the National Institute for Aging and Alzheimer's Association (Albert et al., 2011) This diagnosis is based on psychometric tests, brain imaging and the evolution of cognitive disorders, including an MMSE test.
   • Right-handed person

Exclusion Criteria

• Neurological or psychiatric history with the exception of the TCL group.
• Follow-up of drug treatment in the last three months that may affect cognitive and/or motor skills.
• Received a shoulder prosthesis on the dominant side.
• Received a hip and/or knee replacement less than a year ago.
• Disabling joint disease of the hip or knee shoulder
• Protected adults (curatorship, guardianship)
• Person deprived of their liberty b judicial or administrative decision
• Pregnant, parturient or breastfeeding woman
• Major unable to consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
young neurotypical subjects	Sequence 3	people from 18 to 40 years old
young neurotypical subjects	Sequence 2	people from 18 to 40 years old
elderly neurotypical subjects	Sequence 1	people over 55 years of age
elderly neurotypical subjects	Sequence 2	people over 55 years of age
Elderly subjects with mild cognitive impairment	Sequence 1	people over 55 years of age, with a diagnosis of mild cognitive impairment
young neurotypical subjects	Sequence 1	people from 18 to 40 years old
elderly neurotypical subjects	Sequence 3	people over 55 years of age
Elderly subjects with mild cognitive impairment	Sequence 3	people over 55 years of age, with a diagnosis of mild cognitive impairment
Elderly subjects with mild cognitive impairment	Sequence 2	people over 55 years of age, with a diagnosis of mild cognitive impairment

Primary Outcome Measures

Name	Time	Method
Sequence 1: symmetry ratio of the finger speed profile	through study completion, an average of 3 years
Sequence 2 : perception bias (error in degrees of angle) of dynamic subjective visual vericality	through study completion, an average of 3 years
Sequence 3 : activation time of the focal muscles in relation to the postural muscles	through study completion, an average of 3 years

Trial Locations

Locations (1)

Chu Dijon Bourgogne; 🇫🇷 Dijon, France