Is treatment with octreotide effective in patients with head-and-neck paraganglioma?

Completed

• Conditions: glomustumor; paraganglioma; 10014710

• Registration Number: NL-OMON30072
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Study Completion: 2012-10-19
• Results First Posted: 2022-11-15
• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 4

Inclusion Criteria

-presence of one or more head-and-neck paraganglioma that grow fast (>/ 20%/year) and/or are complicated by recent cranial nerve palsy (<1 year ago)and/or production of catecholamines
-age 18-75 years
-positieve octreotidescan
-informed consent

Exclusion Criteria

-necessity for surgical resection of the head-and-neck paraganglioma
-presence of additional paraganglioma in the thorax or abdomen
-presence of metastases of the head-and-neck paraganglioma
-cholelithiasis
-diabetes mellitus
-severe renal insufficiency (creatinine > 150 micromol/L), or liver failure(ALAt and/or ASAT increased >3x)
-recent participation in other research projects (< 3 month's ago), or participation in >2 projects the past year
-(wish for) pregnancy
-presence of an adrenal tumor, suspect for phaeochromocytoma. These patients will be operated (adrenalectomy) first. In all other patients who participate, an MIBG scan and an MRI svan will be performed in case of overproduction of catecholamines

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. tumorvolume<br /><br>2. catecholamine produktion </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>clinical and biochemical parameters (symptoms, related to the head-and-neck<br /><br>paraganglioma and/or additional catecholamine production, blood pressure and<br /><br>pulse rate, 24 hour blood pressure)</p><br>