The Effect of Eggs on Postprandial Metabolism: A Randomized, Controlled Crossover Pilot Study in Older, Overweight Adults

Tufts University1 site in 1 country20 target enrollmentApril 2011

ConditionsHealthy

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy
Sponsor: Tufts University
Enrollment: 20
Locations: 1
Primary Endpoint: Postprandial change in blood glucose concentration compared to placebo
Status: Completed
Last Updated: 11 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The objective of this randomized, double-blinded, placebo-controlled, 3-way crossover pilot study is to determine whether eggs can favorably alter biomarkers of postprandial metabolism when included with other cooked breakfast foods typically selected by older Americans.

Registry

clinicaltrials.gov

Start Date

April 2011

End Date

August 2014

Last Updated

11 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

Tufts University

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Men \& postmenopausal women, aged 50-70 years
•BMI 28-34 kg/m2

Exclusion Criteria

•Cigarette smoking and/or nicotine replacement use
•Individuals taking estrogen
•Use of cholesterol-lowering medications
•Use of blood pressure-lowering medications
•Regular use of any stomach acid-lowering medications or laxatives (including fiber supplements)
•Cardiovascular (heart) disease
•Gastrointestinal disease
•Kidney disease
•Endocrine disease: including diabetes, untreated thyroid disease
•Rheumatoid arthritis

Outcomes

Primary Outcomes

Postprandial change in blood glucose concentration compared to placebo

Time Frame: 0-4 h

Biomarkers of glucoregulation and insulin sensitivity, inflammation, lipid peroxidation, antioxidant activity, and satiety hormone production will be assessed in blood and urine