NCT01351207已完成不适用
The Effect of Eggs on Postprandial Metabolism: A Randomized, Controlled Crossover Pilot Study in Older, Overweight Adults
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Postprandial change in blood glucose concentration compared to placebo
研究概览
简要总结
The objective of this randomized, double-blinded, placebo-controlled, 3-way crossover pilot study is to determine whether eggs can favorably alter biomarkers of postprandial metabolism when included with other cooked breakfast foods typically selected by older Americans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men & postmenopausal women, aged 50-70 years
- •BMI 28-34 kg/m2
排除标准
- •Cigarette smoking and/or nicotine replacement use
- •Individuals taking estrogen
- •Use of cholesterol-lowering medications
- •Use of blood pressure-lowering medications
- •Regular use of any stomach acid-lowering medications or laxatives (including fiber supplements)
- •Cardiovascular (heart) disease
- •Gastrointestinal disease
- •Kidney disease
- •Endocrine disease: including diabetes, untreated thyroid disease
- •Rheumatoid arthritis
- •Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- •Systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 95 mmHg
- •Regular use of oral steroids
- •Regular daily intake of ≥ 2 alcoholic drinks
- •Vegetarians
- •Allergy to eggs
- •Avoidance and/or intolerance of pork products
- •No dietary supplements, including those containing any vitamins, minerals,herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission
研究组 & 干预措施
pork sausages and hash brown potatoes plus eggs
Active Comparator
干预措施: Eggs (Other)
pork sausages and hash brown potatoes plus egg-free pudding
Placebo Comparator
干预措施: Eggs (Other)
pork sausages and hash brown potatoes
Placebo Comparator
干预措施: Eggs (Other)
结局指标
主要结局
Postprandial change in blood glucose concentration compared to placebo
时间窗: 0-4 h
Biomarkers of glucoregulation and insulin sensitivity, inflammation, lipid peroxidation, antioxidant activity, and satiety hormone production will be assessed in blood and urine
次要结局
未报告次要终点
研究者
研究点 (1)
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