Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths

Not Applicable

Completed

• Conditions: Coronary Artery Disease; Heart Rate; Autonomic Nervous System Disease; Blood Pressure
• Interventions: Other: Protocol Beet and Resveratrol; Other: Placebo Protocol; Other: Protocol Beet; Other: Protocol Resveratrol

• Registration Number: NCT06095635
• Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho

Brief Summary

Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-10
• Primary Completion: 2023-01-10
• Study Completion: 2023-09-30
• Status Verified: 2023-10
• Study First Submitted: 2023-10-04
• Study First Submitted QC: 2023-10-18
• Last Update Submitted: 2023-10-18
• Study First Posted: 2023-10-23
• Last Update Posted: 2023-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 17

Inclusion Criteria

• adult men over 45 years of age
• diagnosed with ischemic coronary artery disease and with preserved left ventricular function (above 50%), confirmed by a previous echocardiogram

Exclusion Criteria

Volunteers who present at least one of the following characteristics will be excluded:

• smokers
• alcohol drinkers
• those who did not attend a cardiovascular rehabilitation program for at least 3 months prior to data collection
• individuals who have known infections, metabolic and respiratory diseases that could interfere in cardiac autonomic control, unstable angina, uncontrolled hypertension, significant valvular disease, uncontrolled metabolic disease (e.g., uncontrolled diabetes and thyroid disease)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Protocol Beet and Resveratrol	Protocol Beet and Resveratrol	exercise and beet extract 500mg and resveratrol capsules 500 mg
Placebo Protocol	Placebo Protocol	exercise and placebo capsules 500 mg (starch)
Protocol Beet	Protocol Beet	exercise and beet extract 500 mg
Protocol Resveratrol	Protocol Resveratrol	exercise and resveratrol capsules 500 mg

Primary Outcome Measures

Name	Time	Method
Heart rate variability (HRV)	through study completion, an average of 1 hour	Time and frequency domain of HRV

Secondary Outcome Measures

Name	Time	Method
Blood Pressure	through study completion, an average of 1 hour	Systolic Blood Pressure and Diastolic Blood Pressure

Trial Locations

Locations (1)

Universidade Estadual Paulista; 🇧🇷 Presidente Prudente, São Paulo, Brazil