The Use of Ketamine Versus Methohexital for Electroconvulsive Therapy: A Cross-Over Comparative Study on Patient Recovery and Re-Orientation Time
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of New Mexico
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Re-orientation Time
Study Overview
Brief Summary
When undergoing ECT treatments, patient recovery time and re-orientation time may be shorter using ketamine for induction than using methohexital.
Detailed Description
ECT treatments are done under general anesthesia, and the induction is commonly done with methohexital. We will study whether using ketamine as an induction agent will result in a faster recovery time and quicker re-orientation time compared to using methohexital.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •All patients eligible for ECT with a primary mood disorder (bipolar disorder, major depressive disorder) will be eligible to participate in this study. - Patients must have decisional capacity and must be able to consent for this study.
Exclusion Criteria
- •patients with a primary psychotic disorder (schizophrenia, schizoaffective disorder); patients designated as having an American Society of Anesthesiologist (ASA) Status of greater than 3;
- •patients with a known allergic reactions to methohexital , ketamine and succinylcholine;
- •patients with current or previous history of aneurysms, intracranial bleeds, or intracranial hypertension;
- •patients with uncontrolled severe hypertension.
Arms & Interventions
Ketamine First
This arm will receive ketamine for induction first, followed by alternating treatments between methohexital and ketamine
Intervention: Ketamine (Drug)
Ketamine First
This arm will receive ketamine for induction first, followed by alternating treatments between methohexital and ketamine
Intervention: Methohexital (Drug)
Methohexital First
This arm will receive Methohexital first for induction, followed by alternating treatments between ketamine and methohexital.
Intervention: Ketamine (Drug)
Methohexital First
This arm will receive Methohexital first for induction, followed by alternating treatments between ketamine and methohexital.
Intervention: Methohexital (Drug)
Outcomes
Primary Outcomes
Re-orientation Time
Time Frame: 1 hour
Patients will be scored based on 5 questions (name, age, year, day of week, location). Each patient will be scored prior to induction as to how many questions they score correctly. Patient is deemed re-oriented when they score the same as baseline after the treatment.
Recovery Time
Time Frame: 1 hour
Recovery was assessed using 5 criteria (blood pressure, voluntary movement, oxygen requirement, consciousness, respiratory effort). Each criteria was scored from 0-2, with a full score of 10. The patient is scored at baseline, and is deemed recovered when all criteria has reached baseline score again.
Secondary Outcomes
No secondary outcomes reported