Use of Ketamine vs Methohexital for Electroconvulsive Therapy (ECT) on Patient Recovery and Re-orientation Time

Not Applicable

Completed

• Conditions: Post-anesthesia Recovery; Orientation
• Interventions: Drug: Ketamine; Drug: Methohexital

• Registration Number: NCT01567852
• Lead Sponsor: University of New Mexico

Brief Summary

When undergoing ECT treatments, patient recovery time and re-orientation time may be shorter using ketamine for induction than using methohexital.

Detailed Description

ECT treatments are done under general anesthesia, and the induction is commonly done with methohexital. We will study whether using ketamine as an induction agent will result in a faster recovery time and quicker re-orientation time compared to using methohexital.

Study Timeline

• Study Start: 2011-08
• Study First Submitted: 2012-03-28
• Study First Submitted QC: 2012-03-29
• Study First Posted: 2012-03-30
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Results First Submitted: 2014-05-21
• Status Verified: 2014-06
• Results First Submitted QC: 2014-12-15
• Last Update Submitted: 2014-12-15
• Results First Posted: 2014-12-30
• Last Update Posted: 2014-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• All patients eligible for ECT with a primary mood disorder (bipolar disorder, major depressive disorder) will be eligible to participate in this study. - Patients must have decisional capacity and must be able to consent for this study.

Exclusion Criteria

• patients with a primary psychotic disorder (schizophrenia, schizoaffective disorder); patients designated as having an American Society of Anesthesiologist (ASA) Status of greater than 3;
• patients with a known allergic reactions to methohexital , ketamine and succinylcholine;
• patients with current or previous history of aneurysms, intracranial bleeds, or intracranial hypertension;
• patients with uncontrolled severe hypertension.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Methohexital First	Ketamine	This arm will receive Methohexital first for induction, followed by alternating treatments between ketamine and methohexital.
Ketamine First	Ketamine	This arm will receive ketamine for induction first, followed by alternating treatments between methohexital and ketamine
Ketamine First	Methohexital	This arm will receive ketamine for induction first, followed by alternating treatments between methohexital and ketamine
Methohexital First	Methohexital	This arm will receive Methohexital first for induction, followed by alternating treatments between ketamine and methohexital.

Primary Outcome Measures

Name	Time	Method
Re-orientation Time	1 hour	Patients will be scored based on 5 questions (name, age, year, day of week, location). Each patient will be scored prior to induction as to how many questions they score correctly. Patient is deemed re-oriented when they score the same as baseline after the treatment.
Recovery Time	1 hour	Recovery was assessed using 5 criteria (blood pressure, voluntary movement, oxygen requirement, consciousness, respiratory effort). Each criteria was scored from 0-2, with a full score of 10. The patient is scored at baseline, and is deemed recovered when all criteria has reached baseline score again.

Trial Locations

Locations (1)

University of New Mexico; 🇺🇸 Albuquerque, New Mexico, United States