Development of novel multinuclear magnetic resonance techniques in healthy volunteers and healthy patients

Cambridge University Hospitals NHS Foundation Trust0 个研究点目标入组 120 人开始时间: 2023年11月14日最近更新: 2024年8月5日

适应症

试验速览

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•Inclusion criteria for healthy volunteers:
•1. Over 18 years old
•2. Able to and provide written informed consent to participate
•3. If female, postmenopausal or if women of childbearing potential (WOCBP) using a suitable form of contraception
•4. Capable of undergoing a minimum of one study visit
•Inclusion criteria for healthy patients at risk for hereditary metabolic disease:
•1. Over 18 years old
•2. Able to and provide written informed consent to participate
•3. If female, postmenopausal or if of childbearing potential (WOCBP) using a suitable form of contraception
•4. Capable of undergoing a minimum of one study visit
•5. Carrying a pathogenic variant in the genes for succinate dehydrogenase and undergoing asymptomatic surveillance but without tumour manifestation

•The presence of any of the following will preclude participation as determined by the delegated investigator:
•1. Contraindication or inability to tolerate MRI
•2. Pregnant or actively breastfeeding woman
•3. If using an intrauterine contraceptive device (IUCD) as a method of contraception the device should be MRI-safe at 3 T (researcher to confirm)
•4. Clinically significant cardiac, pulmonary or neurological diseases as determined by the investigators
•5. Laboratory abnormalities that may impact the study results although no screening will be required for entry into the study.
•6. Any other significant medical or psychiatric history rendering the subject ineligible as deemed by the investigators

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