Effect of anthocyanin-rich food intake on reduction of cardiovascular risk factors

Not Applicable

Completed

• Conditions: Oxidative stress and /or risk factors for cardiovascular disease; Circulatory System

• Registration Number: ISRCTN59129089
• Lead Sponsor: niversity of Milan (Università degli Studi di Milano) (Italy)

Brief Summary

2016 results in https://pubmed.ncbi.nlm.nih.gov/26602318/ (added 10/05/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2014-05-01
• Study Start: 2014-06-05
• Last Update Posted: 24 May 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

1. Healthy men/women smokers (20-35 years of age)
2. Moderate smoking (about 10-15 cigarette/day)
3. Moderate physical activity (25-30 min per day of brisk walk or jog)
4. Moderate alcohol consumption (up to 14 drinks per week)

Exclusion Criteria

1. Individuals with hypertension (systolic blood pressure > 140 mm Hg and/or diastolic blood pressure > 90 mm Hg), hyperglycemia (> 180 mmol/L), hypertriglyceridemia (=1.69 mmol/L) and hypercholesterolemia (=5.17 mmol/L), low HDL cholesterol (<1.03 mmol/L), high LDL cholesterol (=3.36 mmol/L), overweight (BMI >25)
2. History of cardiovascular, coronary, diabetes, hepatic, renal, or gastrointestinal diseases, traumas of the arms or hand, fingers, atopic dermatitis, thyroid disturbance, depression, anxiety, palpitations and chronic backache
3. Use of any drugs, supplements, specific prebiotics or prebiotics or medications at least one month before the beginning of the experiment
4. Volunteers who did not eat fruits and vegetables
5. Difference in dietary habits in particular for food rich in antioxidant compounds: high (> 5 portions/day) or low (<2 portions/day) intake of fruit and vegetables
6. Vegetarian, vegan or macrobiotic

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. The reduction of endogenous oxidized DNA bases and the resistance to H2O2-induced DNA damage (evaluated in blood mononuclear cells by Comet assay)<br> 2. Improvement of peripheral vascular function (measured by a non-invasive pletismographic method).<br> The outcomes are measured before and after the blueberry or placebo treatment and at specific time points.<br>