COMPARISON OF BIOMARKERS IN PATIENTS DIABETIC MELLITUS AND GUM DISEASES

Not Applicable

Conditions: Health Condition 1: K053- Chronic periodontitis

Registration Number: CTRI/2023/04/051270

Lead Sponsor: I

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1.Individual with age ranging from 30-70 years

2.Subjects with minimum 15 teeth or more

3.Generalized chronic periodontitis patients exhibiting

Pocket depth >4mm and CAL of >3mm in more than 30% diseased sites,(According to the AAP classification 2017 stage III grade B in group I and stage III grade C in group II)

GROUP SPECIFIC INCLUSION CRITERIA

GROUP I: Individuals without systemic diseases and chronic periodontitis

GROUP II: Generalized chronic periodontitis patients exhibiting

Pocket depth >4mm and CAL of >3mm in more than 30% diseased sites

According to American Diabetic Association(ADA) classification of glycaemic control-

GROUP III: Generalized chronic periodontitis patients with type 2 diabetes mellitus exhibiting good control

GROUP IV: Generalized chronic periodontitis patients with type 2 diabetes mellitus exhibiting poor control

Exclusion Criteria

1.Patients with systemic condition influencing the course of periodontal disease other than diabetes

2.Patients with haemoglobinopathies, bleeding and clotting disorders that will influence HbA1c level.

3.History of periodontal treatment within the previous six months

4.Antimicrobial therapy, immunosuppressant or lipid lowering drugs within the past 3 months

5. Smokers and alcoholics

6.Pregnancy and lactation

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Plaque Index (Sillness and Loe, 1964)(PI) <br/ ><br>2.Gingival Index(Loe and Sillness,1963)(GI) <br/ ><br>3.Bleeding on probing(BOP) <br/ ><br>4.Probing Depth (PD) <br/ ><br>5.Clinical attachment level (CAL) <br/ ><br>6.HbA1c level (According to American Diabetic Association,ADA) <br/ ><br> <br/ ><br>Timepoint: BASELINE AND 3 MONTHS <br/ ><br> <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
To compare and correlate sTWEAK, Omentin-1 and TNF-Î± levels with clinical parameters (bleeding on probing, probing pocket depth and clinical attachment level) in all 4 groups before and after non-surgical periodontal therapy <br/ ><br>Timepoint: BASELINE AND 3 MONTHS