How a Patient's Words Change the Rewarding Value of Food: Mapping the Neurocognitive Shift Generated by Motivational Interviewing During the Therapy of Food Addiction Onto the Brain - MOTIVFOOD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- BOLD signal difference between talk types
研究概览
简要总结
Why in some situations can words soothe our cravings? This research proposal will test the power of self-generated reasons for behavioural change in food addiction, which concerns about three out of ten persons and causes major life hazards such as obesity, diabetes and cancer. While food addiction is becoming more and more frequent in western societies, not much is known about its underlying neurocognitive mechanisms and how to tackle it. This study aims to investigate if and why certain types of affirmation-based therapies such as motivational interviewing (MI) are beneficial for the treatment of food addiction. The working hypothesis proposes that cognitive regulation-based self-control underpins the neurocognitive shift of a patient's willingness to change addictive behaviour, generated by the patient during MI therapy of food addiction. To test this hypothesis this study combines functional magnetic resonance imaging with behavioural testing of dietary decision-making following a participant's change or sustain talk statements. It will compare three groups of participants with and without food addiction and obesity and lean controls. This study will contribute to the improvement of therapies based upon talking oneself in and out of addiction promoting goals. Findings will provide a better understanding of how our everyday life dietary decision-environments prompt good intentions such as improving long-term nutritional quality to actual behaviours such as forgoing immediate desire.
详细描述
Food addiction is a growing problem that currently concerns 1 out of 5 persons in Western societies. Although food intake is essential to survival and well-being, research in animals and humans has provided convergent evidence that certain types of high palatable, fat- and sugar-rich foods (hp foods) can become as addictive as cocaine or amphetamines. However, in humans, the underlying neurocognitive mechanisms of food addiction are to date unknown, and successful treatment is to be found.
An approach that has been shown to lead to promising results during drug abuse rehabilitation involves Motivational interviewing (MI). MI is a goal-oriented style of communication and focuses on resolving a patient's ambivalence while eliciting his/her own reasons to change addictive behavior, also known as change talk. Functional magnetic resonance imaging (fMRI) studies have shown that patients' individual change talk recordings from prior MI sessions attenuated very, and enhanced dorsolateral prefrontal cortex (dlPFC) responses to addictive drug cues. This finding suggests that a neurocognitive shift in the patients' attitude toward his/her addiction is considered to play a key role in rehabilitation and recovery. However, it is unknown what exactly this neurocognitive shift means on a joint behavioral and neural level. MOTIVFOOD aims to shed light on these dynamics in the context of food addiction.
Hypotheses
- Change compared to sustain talk in obese food addicts alters responses within the brain's valuation and self-control systems, and dietary self-control and food valuation on the behavioral level.
- Food-addicted obese participants will be compared to (a) non-food addicted obese, and (b) to normal weight control participants to explore potential differences in dietary decision-making after the change and after sustain talk on the neural and behavioral level. Expected results are that the MI approach only works when participants are willing and need to engage in therapy. If so, the contrast between change and sustain talk statements should be stronger, when behavior needs indeed to be changed because of (a) obesity, which is a major life hazard, and/or (b) food addiction, for which MI was designed for.
Design Plan
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group: Normal-weight, NON-food addicted control participants
- •no food addiction, no eating disorder, no nutrition troubles, no weight management troubles
- •BMI: between 18.5 kg/m2 and 25 kg/m2
- •age 18 to 70 years
- •right-handed
- •male / female
- •able to understand instructions and perform tasks
- •no psychiatric or neurological disorders
- •no drug abuse
- •written and informed consent
- •Group: obese, food addicted
- •BMI >= 30 kg/m2
- •YFAS score > = 2
- •no other addictions
- •age 18 to 70 years
- •right-handed
- •male / female
- •able to understand instructions and perform tasks
- •no recently diagnosed psychiatric or neurological disorders
- •no drug abuse
- •written and informed consent
- •Group: obese, NON-food addicted
- •age 18 to 70 years
- •BMI >= 30 kg/m2
- •YFAS score < =1
- •no other addictions
- •right-handed
- •male / female
- •able to understand instructions and perform tasks
- •no recently diagnosed psychiatric or neurological disorders
- •no drug abuse
- •written and informed consent
排除标准
- •bad MRI quality
研究组 & 干预措施
Normal-weight, NON-food addicted
干预措施: Motivational interviewing (Behavioral)
obese food addicted
干预措施: Motivational interviewing (Behavioral)
obese NON-food addicted
干预措施: Motivational interviewing (Behavioral)
结局指标
主要结局
BOLD signal difference between talk types
时间窗: 30 minutes
contrast in BOLD signal between change and sustain talk in food-addicted obese participants
次要结局
- Self control during dietary decision-making(30 minutes)
- Food addiction one month after motivational interviewing(15 minutes)
- dietary habits one month after motivational interviewing(15 minutes)
- BOLD signal difference between talk types and participant groups(30 minutes)