The efficacy of methylprednisolone mini pulse on the treatment of COVID-19 patients admitted to intensive care unit

Phase 3

• Conditions: COVID-19 Disease.; COVID-19; U07.2,

• Registration Number: IRCT20170716035126N4
• Lead Sponsor: Ardabil University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 September 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patient with moderate to severe Covid-19 admitted to ICU
PaO2/FiO2 Less than 300
Progression of disease severity and not responding to standard treatment
prediction of intubation for next 24 hours or those under mechanical ventilation

Exclusion Criteria

,ncontrolled diabetes mellitus
Active GI bleeding
history of corticosteroid hypersensitivity
sever electrolyte imbalances
History of treatment with immune-suppressor agents
History of corticosteroid use
Positive procalcitonin
active bacterial or fungal infection
HIV and hepatitis

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality rate. Timepoint: from including to study to 60 days. Method of measurement: observation.;Blood O2 saturation. Timepoint: before and during the study for 14 days. Method of measurement: pulse Oximeter.;Oxygen therapy need. Timepoint: before and during the study for 14 days. Method of measurement: Clinical.