Acute Effects of Whole Body Blue Light Exposure on Blood Pressure
- Conditions
- Blue Light
- Interventions
- Procedure: Blue lightProcedure: control exposure
- Registration Number
- NCT03226587
- Lead Sponsor
- Heinrich-Heine University, Duesseldorf
- Brief Summary
Ultraviolet light exposure was shown to be able to release nitric oxide from the skin into the blood stream and lead to an acute decrease in blood pressure and increase in vascular function. Additionally, preliminary work indicates that UV free blue light also releases nitric oxide in the skin mediating similar effects as seen with ultraviolet light A(UVA). It is the goal of the present experimental study to investigate the hemodynamic effects of whole body blue light exposure including blood pressure, endothelial function and vascular stiffness. Therefore, healthy volunteers will be exposed to 30 minutes whole body blue light (453 nm wavelength) and the change in blood pressure and endothelial function (Flow mediated dilation (FMD)), heart rate, forearm-blood flow, forearm vascular resistance central blood pressure and vascular stiffness ( pulse wave analysis by sphygmocor) will be measured.
In this randomized controlled cross-over study, 20 healthy subjects aged 30 to 60 years will participate.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 20
- healthy, male subjects
- age between 30 and 60 years
- signed patient informed consent
- diabetes mellitus
- acute inflammation (CRP >0.5mg/dl)
- cardiac arrythmia
- active cancer
- renal failure
- heart failure (NYHA II-IV)
- arterial hypotension (systolic pressure <100 mmHg)
- treatment with antihypertensive drugs
- dermatosis of the eyelid
- porphyria or hypersensitivity to porphyrins
- congenital or aсquired immune deficiency
- genetic conditions that cause an increased sensitivity to light or an increased risk to dermatological cancer (such as xeroderma pigmentosum, cockayne syndrome, bloom syndrome)
- previous intake or use of photosensitizing drugs, food or cosmetics (e.g. psychiatric medication, antibiotics, cardiovascular drugs, hormone, Hypericum, Bergamot orange) or use of perfumes
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Blue light Blue light Each subject will be undergo a whole body exposure to blue light (453 nm wavelength) for 30 minutes. Control exposure control exposure Each participant will also undergo a control examination, where the body will be covered with a light tight foil during blue light exposure for 30 minutes.
- Primary Outcome Measures
Name Time Method Change of peripheral blood pressure baseline, during 30 min exposure and 2 hours thereafter Change of peripheral blood pressure as measured before, during and up to 2 hours after 30 min blue light as compared to control
- Secondary Outcome Measures
Name Time Method Change from baseline forearm blood flow baseline, during 30 min exposure and 2 hours thereafter measured by ultrasound before, immediately after 30 min exposure and at 2 h thereafter
Change from baseline NO-species baseline, during 30 min exposure and 2 hours thereafter determined by chemiluminescence before, immediately after 30 min exposure and at 2 h thereafter
Change from baseline heart rate baseline, during 30 min exposure and 2 hours thereafter measured by electrocardiography (ECG) before, during and up to 2 hours after 30 min blue light as compared to control
Change from baseline central blood pressure baseline, during 30 min exposure and 2 hours thereafter measured by applanation tonometry before, immediately after 30 min exposure and at 2 h thereafter
Change from baseline forearm vascular resistance baseline, during 30 min exposure and 2 hours thereafter measured by ultrasound before, immediately after 30 min exposure and at 2 h thereafter
Change from baseline Endorphins baseline, during 30 min exposure and 2 hours thereafter measured before, immediately after 30 min exposure and at 2 h thereafter
Change in endothelial function baseline, during 30 min exposure and 2 hours thereafter measured by flow mediated dilation (FMD) before, immediately after 30 min exposure and at 2 h thereafter
Change from baseline vascular stiffness baseline, during 30 min exposure and 2 hours thereafter measured by applanation tonometry before, immediately after 30 min exposure and at 2 h thereafter
Change from baseline Cortisol baseline, during 30 min exposure and 2 hours thereafter measured before, immediately after 30 min exposure and at 2 h thereafter
Trial Locations
- Locations (1)
Division of Cardiology, Pulmonary Disease and Vascular Medicine
🇩🇪Düsseldorf, NRW, Germany