A Biobehavioral Model of Diabetes Risk in Chinese Immigrants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 650
- 试验地点
- 1
- 主要终点
- Insulin resistance
研究概览
简要总结
This prospective, longitudinal study of Chinese American immigrants will examine whether psychosocial factors (e.g., acculturative stress, social isolation, discrimination) are associated with markers of type 2 diabetes risk over time, and whether such associations are mediated by inflammatory pathways.
详细描述
It is now well-documented that immigration to the US leads to increased risk for various chronic diseases, including type 2 diabetes. The increased diabetes risk observed among Chinese immigrants has been primarily attributed to changes in diet and weight gain following immigration, but these changes can only partially explain disparities in disease risk. Models of immigrant health suggest that the stress of adapting to life in a new country has a considerable impact on physical health. However, few studies have considered the psychosocial impact of immigration upon biomarkers of health and disease risk. Therefore, this longitudinal study of US Chinese immigrant men and women will examine: (1) whether psychosocial factors (e.g., acculturative stress, social isolation, discrimination) are associated with markers of type 2 diabetes risk over time; and (2) whether the association between psychosocial factors and diabetes risk markers is mediated by inflammatory pathways.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Chinese heritage;
- •migration from Asia in adulthood (aged 18 years or older); and
- •age 35-65 years
排除标准
- •Current or prior history of diabetes
- •Self-reported conditions of cancer, auto-immune disorders, HIV, or psychiatric illness
- •Use of medications that may impact study outcomes (e.g., steroidal or non-steroidal anti-inflammatory medications)
- •Inability to provide informed consent.
结局指标
主要结局
Insulin resistance
时间窗: 24 months post-baseline
Insulin resistance will be estimated according to the homeostasis model assessment (HOMA) as HOMA = (fasting insulin x fasting glucose) / 22.5
次要结局
- glycated hemoglobin (HbA1c)(24-months post-baseline)