跳至主要内容
临床试验/CTRI/2024/08/072359
CTRI/2024/08/072359招募中不适用

An Observational Prospective Study To Evaluate The Correlation Of Handgrip Strength With RCRI and Lab Investigations For Preoperative Assessment Of Fraility In Patients Undergoing Lower Limb Orthopaedic Surgeries

Bharati Hospital and Research Centre1 个研究点 分布在 1 个国家目标入组 95 人开始时间: 2024年8月20日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
95
试验地点
1
主要终点
PRIMARY OBJECTIVE

研究概览

简要总结

Aging is a global phenomenon and the elderly adults carry an increasing burden of chronic illnesses which affect their overall health and well-being. Fraility is identified by decreased reserves in multiple organ systems. Fraility has been known to be associated with postoperative adverse events and Longer Hospital Length of Stay (LOS). Identifying frail patients has always been an important part of improving post operative outcome. Assessing the skeletal muscle reserves has been an integral part of predicting the nutritional status of the patient and also the post-operative outcome.Estimates of skeletal protein and plasma albumin concentrations is useful in detecting malnutrition. Hypoalbuminemia accurately reflects malnutrition and a low preoperative albumin concentration was associated with high post-operative complications. Researchers have defined appreciable protein depletion as existing when arm muscle circumference is below 85% of the standard, hand grip strength is below 85% of normal, or plasma albumin concentration below 35 g/l. Handgrip dynamometry is a sensitive screening test to detect preoperative malnutrition and predict postoperative complications. Hand grip strength (HGS) is used to diagnose both sarcopenia and frailty. Low grip strength is consistently associated with a greater likelihood of premature mortality, development of disability and an increased risk of complications. the gold standard of risk stratification in pre-operative settings include the use of the Revised Cardiac Risk Index (RCRI). Previous studies have concluded that a weaker Hand grip strength was significantly associated with lower levels of serum albumin, higher RCRI score, and a longer hospital LOS in patients undergoing major surgery.

研究设计

研究类型
Observational

入排标准

年龄范围
65.00 Year(s) 至 99.00 Year(s)(—)
性别
All

入选标准

  • 1.patients of the age above 65 of either sex 2.ASA I / II / III patients 3.patients undergoing elective lower limb Orthopedic surgeries under central neuraxial blockade.

排除标准

  • Patients who are not willing to take part in the study.
  • Patients with pathological defects such as paralysis, arthritis, and trauma that obviously impair grip strength will be excluded 3)Patients who are unable to comprehend the commands or use the dynamometer freely 4)Patients with coagulopathy, spinal deformities and other contraindications to central neuraxial blockade 5)Patients posted for emergency Orthopedic surgeries.

结局指标

主要结局

PRIMARY OBJECTIVE

时间窗: the patient will be assessed in the preoperative period, intraoperative period and the immediate postoperative period.

-To assess the Handgrip Strength in the Preoperative period

时间窗: the patient will be assessed in the preoperative period, intraoperative period and the immediate postoperative period.

-To assess Intra Operative and Post-Operative outcomes like blood loss, Inotrope requirement, post operative ICU stay and length of hospital stay.

时间窗: the patient will be assessed in the preoperative period, intraoperative period and the immediate postoperative period.

-To Compare the Grades of Hand Grip Strength with the Intra and Post Operative Outcomes.

时间窗: the patient will be assessed in the preoperative period, intraoperative period and the immediate postoperative period.

次要结局

  • SECONDARY OBJECTIVE(To Correlate Handgrip Strength with other Frailty Measurements(investigations) like-)

研究者

发起方
Bharati Hospital and Research Centre
申办方类型
Research institution and hospital
责任方
Principal Investigator
主要研究者

Dr Athira CN

Bharati Vidyapeeth (DTU) University, Pune

研究点 (1)

Loading locations...

相似试验