To know the effect of two varieties of enema pattern with Panchamoolabalasiddha Ksheera in Osteoarthritis

Phase 2/3

Not yet recruiting

• Conditions: Osteoarthritis of knee, unspecified. Ayurveda Condition: SANDHIGATAVATAH,

• Registration Number: CTRI/2022/09/046006
• Lead Sponsor: DrTejali Chandrakant Rohidas

Brief Summary

In *Panchakarma, Basti* is considered as “*Ardhachikitsa*†in the management of disease. When *Basti* is administered, it reaches *pakwashaya* and removes *dosha* from all over the body.It is the best treatmentline for *Asthyashrayaja vyadhi.*As per *Acharya Charaka*, *Basti* is mentioned as *Vataharanam shrestam.So* it is helpful in *vataja*diseases like *Janu Sandhigatavata*where *vriddhi*in *Ruksha guna of vata and kshaya* of *shleshakakapha*produces pain and stiffness of knee joint during movement. All *Vatavyadhi*requires *shodhana* along with *brumhana*line of treatment*. Acharya Sushruta* has mentioned that 9-11 *Anuvasana Basti* is required for *vata* predominant diseases.This is fulfilled by *Kala Basti* pattern of *Acharya Kashyapa*and *Acharya Vagbhata.**Janu Sandhigatavata* is *vatajavyadhi*presented with symptoms of *Sandhishoola,**vatapurnadrutisparshashotha**and prasaranaakunchana vedana.*It has symptoms similar to osteoarthritis of knee in conventional science. OA is age related chronic degenerative disease characterized by deterioration of cartilage of joints that results in bone rubbing together and creating stiffness, pain and impairment in movement.

Osteoarthritis is second most common rheumatological problem with prevalence of 22% to 39% in India. By 2025 India may become the osteoarthritis capital of the world with over 60 million cases. Almost all persons over the age 40 have some bodily transformation in weight bearing joints. And this prevalence of OA is increasing with age and risk factors.The treatment of osteoarthritis mainly focuses on pain management using NSAIDS, Topical Analgesics, corticosteroids injection and lastly joint replacement surgery.  As OA is an inevitable part of ageing, there is no other satisfactory treatment. As long-term intake of oral medication has its own side effects, so to deal with chronic joint diseases *Ayurvedic* management seems to be the best.

*Panchamoolabalasiddha Ksheera* is indicated in *Vataja vikara. Acharya Charaka* mentions that whatever the medicine indicated in particular disease can be used in the form of *basti.Panchamoola* (*laghu panchamoola*) contains *tikta,madhura rasa pradhana dravyas having vataghna, brumhana, balavardhana property*, which helps in *samprapti vighatana* of the disease. In present scenario *Kala Basti* mentioned by *Acharya Charaka* is widely practiced, while *Kala Basti* mentioned by *Kashyapa*and *Vagbhata*are usually not in practice, as in today’s era everyone has busy schedule, hence an attempt is made to evaluate the effect of these two patterns of *Kala Basti* having maximum number of *Anuvasana Basti* in minimum duration using *Panchamoolabalasiddha Ksheera Basti* in *Janu Sandhigatavata*.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-01-10
• Last Update Posted: 2022-09-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Subjects fit for Basti Karma.
• Subjects diagnosed with Janu Sandhigatavata.
• Age-40-70yrs of either sex.

Exclusion Criteria

• Fracture of the knee joint.
• Subjects with BMI >30.
• Subjects with secondary OA.
• Subjects with uncontrolled DM, HTN and cardiac disease.
• Malignant condition and congenital deformity.
• Pregnant and lactating women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Sandhi shoola (pain)	Before treatment on -0th day | After completion of treatment-on 10th day and 12th day. | Follow up on -36th day.
2.Sandhisthabdhata (stiffness)	Before treatment on -0th day | After completion of treatment-on 10th day and 12th day. | Follow up on -36th day.

Secondary Outcome Measures

Name	Time	Method
1.Sandhishotha (swelling)	2.Crepitus

Trial Locations

Locations (1)

Government Ayurveda Medical and Hospital ,Bengaluru; 🇮🇳 Bangalore, KARNATAKA, India

Government Ayurveda Medical and Hospital ,Bengaluru

🇮🇳Bangalore, KARNATAKA, India

Dr Tejali Chandrakant Rohidas

Principal investigator

9108097076

tejalirohidas@gmail.com