Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms

Not Applicable

Completed

• Conditions: Atherosclerosis; Chronic Periodontitis
• Interventions: Procedure: Non-surgical periodontal treatment

• Registration Number: NCT02977351
• Lead Sponsor: Izmir Katip Celebi University

Brief Summary

Determine the relationship between the systemic indications of atherosclerosis by means of the change in the ratio of periodontopathogenic microorganisms following periodontal treatment of individuals who have been diagnosed with chronic periodontitis-atherosclerosis and for individuals who have been diagnosed with systemically healthy-chronic periodontitis.

Detailed Description

It has been aimed in this study to compare 1) the change in periodontal status; 2) the change of the periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) in dental plaque samples, 3) the changes of the amounts of HDL, LDL, hs-CRP white blood cell levels (WBC), platelet levels (PLT), creatinine, and fibrinogen in serum samples; and 4) the correlation between periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) and HDL, LDL, hs-CRP WBC, PLT, creatinine, and fibrinogen in patients that have been diagnosed with atherosclerosis-chronic periodontitis and systemic healthy patients and patients diagnosed with chronic periodontitis, following non surgical periodontal treatment.

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2015-01
• Study Completion: 2016-01
• Status Verified: 2016-11
• Study First Submitted: 2016-11-15
• Study First Submitted QC: 2016-11-29
• Last Update Submitted: 2016-11-29
• Study First Posted: 2016-11-30
• Last Update Posted: 2016-11-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• had no systemic disease,
• had not used any antibiotics
• had not used medications with an impact on the immune system,
• had not received any periodontal and/or medical treatment within the last 6 months.

Exclusion Criteria

• smokers of cigarettes or other tobacco products,
• pregnant or breastfeeding,
• non-stable cardiovascular condition.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Systemically healthy	Non-surgical periodontal treatment	Patients with Systemically healthy and chronic periodontitis.
Atherosclerosis	Non-surgical periodontal treatment	Patients with atherosclerosis and chronic periodontitis

Primary Outcome Measures

Name	Time	Method
Periodontopathogenic microorganism levels	1 year