Determining the Relationship Between the Atherosclerosis and Periodontopathogenic Microorganisms in Chronic Periodontitis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atherosclerosis
- Sponsor
- Izmir Katip Celebi University
- Enrollment
- 40
- Primary Endpoint
- Periodontopathogenic microorganism levels
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Determine the relationship between the systemic indications of atherosclerosis by means of the change in the ratio of periodontopathogenic microorganisms following periodontal treatment of individuals who have been diagnosed with chronic periodontitis-atherosclerosis and for individuals who have been diagnosed with systemically healthy-chronic periodontitis.
Detailed Description
It has been aimed in this study to compare 1) the change in periodontal status; 2) the change of the periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) in dental plaque samples, 3) the changes of the amounts of HDL, LDL, hs-CRP white blood cell levels (WBC), platelet levels (PLT), creatinine, and fibrinogen in serum samples; and 4) the correlation between periodontopathogen microorganisms (A. actinomycetemcomitans, P. gingivalis, T. forsythia, T. denticola, P. intermedia, P. micros, F. nucleatum/periodonticum, C. rectus, E. nodatum, E. corrodens, and C. gingivalis/ochracea/sputigena) and HDL, LDL, hs-CRP WBC, PLT, creatinine, and fibrinogen in patients that have been diagnosed with atherosclerosis-chronic periodontitis and systemic healthy patients and patients diagnosed with chronic periodontitis, following non surgical periodontal treatment.
Investigators
Dr. A. Seckin ERTUGRUL
Principal Investigator
Izmir Katip Celebi University
Eligibility Criteria
Inclusion Criteria
- •had no systemic disease,
- •had not used any antibiotics
- •had not used medications with an impact on the immune system,
- •had not received any periodontal and/or medical treatment within the last 6 months.
Exclusion Criteria
- •smokers of cigarettes or other tobacco products,
- •pregnant or breastfeeding,
- •non-stable cardiovascular condition.
Outcomes
Primary Outcomes
Periodontopathogenic microorganism levels
Time Frame: 1 year