"Tidal Volume Challenge :A Practical Tool to Guide Fluid Therapy in the Critically Ill"

Not yet recruiting

• Conditions: Respiratory disorders in diseasesclassified elsewhere,

• Registration Number: CTRI/2025/06/089886
• Lead Sponsor: IGIMS

Brief Summary

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|Volume expansion is a cornerstone treatment of acute circulatory failure like during the early hours in patients with septic shock, but it can be a cause of therapeutic dilemma because fluid overload can lead to acute kidney injury, prolongation of mechanical ventilation, acute respiratory distress syndrome, and higher mortality rates.

Predicting fluid responsiveness with a reliable, easy, and rapid way is essential to know when to start and when to stop fluid therapy especially as patients may react differently to VE.

Static hemodynamic parameters like inferior vena cava diameter and central venous pressure are unreliable and cannot predict FR precisely; contrarily, dynamic parameters that depend on cyclic changes in cardiac preload caused by mechanical ventilation, leading to variation of stroke volume or pulse pressure have proven to be reliable when predicting FR in hemodynamically unstable patient

PPV is a common dynamic parameter that can predict FR reliably and can be recorded through most of recent bedside monitors easily using arterial lines; also, it does not need CO monitoring or any other maneuvers to be done.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-06-28
• Study Start: 2025-07-30

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Adult patients more than 18 years with hemodynamic instability who are intubated and mechanically ventilated with volume assist-control and using low tidal volume strategy.

Exclusion Criteria

• Age less than 18 years 2.Contraindication for PPV( Spontaneous breathing,cardiac arrthymias,open chest,right-side heart failure,pulmonary or intraabdominal hypertension) 3.
• Non consenting.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To Study to compare the sensitivity and specificity of both tests for the prediction of fluid responsiveness in mechanically ventilated patients with hemodynamic instability	18 month

Secondary Outcome Measures

Name	Time	Method
1. See compare hemodynamic changes in 2 groups	2. Side effect of fluid bolus

Trial Locations

Locations (1)

Indira Gandhi institute of medical Sciences,patna; 🇮🇳 Patna, BIHAR, India

Indira Gandhi institute of medical Sciences,patna

🇮🇳Patna, BIHAR, India

Ritu Singh

Principal investigator

8127395753

ritusingh140@gmail.com