Strength Training and Different Subtypes of Parkinson´s Disease

Not Applicable

Completed

• Conditions: Parkinson Disease
• Interventions: Other: Progressive resistance exercise; Other: Physical Activity

• Registration Number: NCT02966600
• Lead Sponsor: University of Oviedo

Brief Summary

The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype). The investigators hypothesized the intervention would have a beneficial effect on the study outcomes.

Detailed Description

Twenty-eight patients with PD AR-type of both sexes, were recruited for this trial. Each participant were assigned randomly to either intervention (N=13) or control (N=15) group.

The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. The control group followed their usual weekly physical activity routine.

All patients underwent antrophometrical and neuromuscular function assessment (CoP measurements -primary outcomes- and the Ten-Meters Walk Test -TMWT- -secondary outcomes-). In addition, they were asked to provide ratings for the Spanish validated versions of the the Freezing of Gait Questionnaire (FOG-Q, 6-item version) -secondary outcomes-, the 39-item Parkinson ́s disease Questionnaire (PDQ39) -secondary outcomes- and the MDS-UPDRS -secondary outcomes-. Additionally, ratings of perceived exertion (RPE) (Borg \>6-20 scale) - secondary outcomes-, were recorded at the end of each PRE training session. Tests were carried out at three times: pre-test (before the training program), post-test (eight weeks after pre-tests, at the end of the training period), and four weeks after the post-test (re-test).

Study Timeline

• Study Start: 2016-02
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2016-11
• Study First Submitted: 2016-11-07
• Study First Submitted QC: 2016-11-14
• Last Update Submitted: 2016-11-14
• Study First Posted: 2016-11-17
• Last Update Posted: 2016-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Diagnosed with PD AR-type and Hoehn and Yahr Scale 1-2, (H&Y)
• Do not express any type of dementia
• Able to stand for two min without assistance;
• Able to walk ten metres without assistance.

Exclusion criteria:

• To suffer a neurological disease other than PD.
• Do not meet some of the inclusion criteria.

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Progressive resistance exercise (PRE)	Physical Activity	Progressive resistance exercise (PRE) in akinetic-rigid Parkinson's disease patients. Intervention included sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one.
Progressive resistance exercise (PRE)	Progressive resistance exercise	Progressive resistance exercise (PRE) in akinetic-rigid Parkinson's disease patients. Intervention included sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one.

Primary Outcome Measures

Name	Time	Method
Static posturography through the centre of pressures measurements (CoP).	Eight weeks

Secondary Outcome Measures

Name	Time	Method
The patient- perceived quality of life.	Eight weeks
Gait.	Eight weeks
Freezing of gait.	Eight weeks
The Movement Disorders Society-Unified Parkinson ́s Disease Rating Scale. (MDS-UPDRS).	Eight weeks

Trial Locations

Locations (1)

University School of Sports Medicine, University of Oviedo, Spain.; 🇪🇸 Oviedo, Asturias, Spain