A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure

Not Applicable

Completed

• Conditions: Acute Liver Failure
• Interventions: Procedure: High volume plasma exchange; Procedure: Standard medical treatment

• Registration Number: NCT00950508
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The aim of this study is to examine if high-volume plasma exchange has a positive effect on mortality in patients with acute liver failure.

Detailed Description

Not available

Study Timeline

• Study Start: 1998-06
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Study First Submitted: 2009-07-29
• Study First Submitted QC: 2009-07-30
• Study First Posted: 2009-07-31
• Status Verified: 2014-11
• Last Update Submitted: 2014-11-04
• Last Update Posted: 2014-11-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 183

Inclusion Criteria

• Patients with acute liver failure in encephalopathy grade 2-4

Exclusion Criteria

• alcoholic hepatitis
• primary non function liver graft or graft dysfunction
• known chronic liver disease
• known malignancies
• clinical suspicion of brain death

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High volume plasma exchange	Standard medical treatment	3 successive plasma exchanges over 3 days
Standard medical treatment	Standard medical treatment	-
High volume plasma exchange	High volume plasma exchange	3 successive plasma exchanges over 3 days

Primary Outcome Measures

Name	Time	Method
mortality	at day 3, day 7

Trial Locations

Locations (3)

Department of Hepatology, Rigshospitalet; 🇩🇰 Copenhagen, DK, Denmark

Institute of Liver Studies, King's College Hospital; 🇬🇧 London, United Kingdom

Department of Transplantation and Liver Surgery, Helsinki University Hospital; 🇫🇮 Helsinki, Finland