PACE4 in Thyroid Cancer

Completed

• Conditions: Thyroid Nodule
• Interventions: Diagnostic Test: Immunohistochemistry

• Registration Number: NCT03160482
• Lead Sponsor: Robert Day

Brief Summary

The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no fully reliable molecular marker for thyroid cancer have been described. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a biomarker.

Detailed Description

Patients that underwent thyroidectomy at the CIUSSS de l'Estrie-CHUS will be recruited and classified according to the pathological diagnosis. An immunohistochemistry technique, developed and calibrated for the specific protein convertase studied, will be undertaken. Results will be interpreted by a specialized pathologist.

Study Timeline

• Study Start: 2017-05-15
• Study First Submitted: 2017-05-16
• Study First Submitted QC: 2017-05-18
• Study First Posted: 2017-05-19
• Primary Completion: 2018-01-15
• Study Completion: 2018-01-15
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-28
• Last Update Posted: 2018-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• Men of women, aged 18-100 y.-o.
• History of subtotal or total thyroidectomy at the "Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke" (CIUSSS de l'Estrie - CHUS) between January 2010 and May 2016.

Exclusion Criteria

• Refusal to participate to the study.
• Unavailability of the formalin-fixed, paraffin-embedded tissues.
• Uncertain pathological diagnosis.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Papillary carcinoma, classical variant	Immunohistochemistry	-
Follicular carcinoma	Immunohistochemistry	-
Papillary carcinoma, follicular variant	Immunohistochemistry	-
Medullary carcinoma	Immunohistochemistry	-
Colloid nodule	Immunohistochemistry	-
Follicular adenoma	Immunohistochemistry	-
Hyperplastic nodule	Immunohistochemistry	-
Adenomatoid nodule	Immunohistochemistry	-
Lymphocytic thyroiditis	Immunohistochemistry	-

Primary Outcome Measures

Name	Time	Method
Expression pattern of the studied protein convertase	Trough study completion, an average of 1 year after the patients have been operated.	Horseradish peroxidase staining with specific antibodies.

Trial Locations

Locations (1)

CIUSSS de l'Estrie - CHUS; 🇨🇦 Sherbrooke, Quebec, Canada