Study of the Cutaneous Reinnervation After Burn With the Aim of a Better Care of Neuropathic Pain and Pruritus After Healing
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Number of the differences of expression of genes coding for regulating proteins of the innervation
研究概览
简要总结
The aim of this study is to understand why the regeneration of the cutaneous sensory nerve fibers is poor in post-burn scar.
The presence or the lack of several molecular factors known to regulate neuronal cell development will be evaluate and compared within biopsies from healthy skin and post-burn scar.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major patients
- •At least one year back deep burn (2nd and 3rd degrees), and allowing the comparison between the post-burn scar dermatome and the healthy opposite dermatome
- •Patients always followed in the service of Plastic surgery of the hospital of Brest
- •Informed consent and paper of the patient after information of the objective of the study and the protocol
- •Analog Visual scales for pain and/or pruritus (EVA): greater than or equal to 3
- •Simple Verbal scales for the pain and/or the pruritus ( EVS): pain / pruritus moderated to intense
- •Membership to the Social Security
排除标准
- •Allergy to xylocaine
- •Non-Caucasian patients
- •Treatments having an effect on the pain and/or the pruritus
- •Sun or UV exposure several days preceding or following the biopsies
结局指标
主要结局
Number of the differences of expression of genes coding for regulating proteins of the innervation
时间窗: 6 months
To evaluate the differences of expression of genes coding for regulating proteins of the innervation on samples of healthy skins and post-burn scar. These biopsies will be removed from post-burn patients (at least one year after burn) and allowing the comparison between conflicting dermatomes: a healthy dermatome and a formerly burned dermatome
次要结局
- Validation of the difference of density of intra-epidermic nerve fibers(6 months)