Adjunctive Glycine for Obsessive Compulsive Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- Y-BOCS (Yale-Brown Obsessive Compulsive Scale)
研究概览
简要总结
The purpose of this study is to determine whether individuals with obsessive compulsive disorder who will take a preparation of the amino acid glycine in addition to their current treatment, may experience improvement in their symptoms.
详细描述
Individuals with obsessive compulsive disorder (OCD) often find inadequate relief, even with the best of currently available treatments. Some evidence suggests the the neurotransmitter glutamate may be a useful target for new treatments for OCD. The amino acid glycine, if given orally in adequate dosages, can have specific effects on one particular glutamate receptor molecule in the brain, that might be helpful with OC symptoms. This randomized, double-blind protocol will have study participants who suffer with OCD take either a glycine preparation or placebo for 12 weeks. Clinical measures (e.g., Y-BOCS, NIMH-OC) will be recorded at each visit to determine whether those taking the glycine experience clinical benefit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of OCD present for at least 1 year
- •Male or female, age 18 to 65
- •Stable medication regimen for 12 weeks prior to study entry
- •at least moderately severe OC symptoms
排除标准
- •Active substance use disorder within the last 6 months
- •Comorbid schizophrenia, schizoaffective disorder, bipolar disorder, tic disorder, Tourette Disorder, schizotypal personality disorder
- •Hoarding as the principal OCD symptom
- •Insulin-dependent diabetes mellitus
- •Pregnant or breastfeeding
研究组 & 干预措施
A
glycine powder
干预措施: glycine (Drug)
B
placebo powder
干预措施: placebo (Other)
结局指标
主要结局
Y-BOCS (Yale-Brown Obsessive Compulsive Scale)
时间窗: 12 weeks after baseline
次要结局
- CGI-Improvement(12 weeks after baseline)
- QLS(Quality of Life Scale)(12 weeks after baseline)
- NIMC-OC scale(12 weeks after baseline)
- Sheehan Disability Scale(12 weeks after baseline)