Abdominal nerve block through ultrasound scanning and local anaesthetic drug deposition inside abdomen through abdominal portsite is compared for providing postoperative pain relief in patients undergoing laparoscopic gall bladder stone surgeries.

Phase 4

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2024/01/061269

Lead Sponsor: Medical College Baroda

Brief Summary: The aim of our study is to evaluate and compare the efficacy of postoperative analgesia provided by Transversus Abdominis Plane block and intraperitoneal instillation of local anaesthetic solution in patients who are undergoing laparoscopic cholecystectomy. 80 patients belonging to the age group 18 to 70 years with ASA status I, II or III are randomly selected into two groups. Group T are those patients who received Ultrasound guided bilateral subcostal Transversus Abdominis plane block using 30mL of 0.25% Bupivacaine local solution just after the induction of general anaesthesia and Group L are those who received intraperitoneal instillation of 30mL of 0.25% of Bupivacaine local solution under vision just after trocar insertion and before the start of the surgery. Intraoperative hemodynamic stability is monitored among the two groups by monitoring the HR,BP,SpO2 and EtCO2. Postoperatively the time taken for the administration of the first dose of rescue analgesia at VAS >=4 is also noted among the two groups. The total amount of postoperative analgesic requirement in 24 hours time period and the VAS scores at 2,4,6,8, 12 and 24 hours are also compared among the two groups.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

ASA grade I II III BMI less than or equal to 30 kg per meter square.

Exclusion Criteria

Patients who refused consent to be part of clinical study Patients with allergy to local anaesthetics Infection at the site of injection Coagulopathy Duration of surgery for more than 3 hours Laparoscopic surgeries that gets converted into open cholecystectomy.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the duration of postoperative analgesia between two groups	Time required for administration of first postoperative rescue analgesia in VAS score more than 4

Secondary Outcome Measures

Name	Time	Method
To monitor intraoperative hemodynamic stability	1min, 5min, 10min, 30min, 60min, 90min, 120min, 150min, 180min
To assess VAS score postoperatively	2hours, 4 hours, 6hours, 8hours, 12hours, 24hours
Total amount of postopeative analgesia administered	24 hours postoperatively

Trial Locations

Locations (1): SSG hospital Medical College Baroda
🇮🇳
Vadodara, GUJARAT, India
SSG hospital Medical College Baroda
🇮🇳Vadodara, GUJARAT, India
Dr Amrutha P
Principal investigator
6354744892
ammulyf@gmail.com