A clinical trial to compare the effects of two drugs, Ceftriaxone and Benzathine Penicillin in the treatment of Early stage of the sexually transmitted disease, Syphilis
Phase 2
- Conditions
- Health Condition 1: A519- Early syphilis, unspecified
- Registration Number
- CTRI/2024/07/071014
- Lead Sponsor
- Government Tirunelveli Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All patients who present in STD Clinics with untreated Early syphilis (Includes Primary, Secondary and Early latent syphilis).
Operational definition for Early syphilis – 1 year from the primary lesion(chancre) or if there is no primary chancre 1 year from the date of last contact with REACTIVE RPR & Confirmed by POSITIVE TPHA
Exclusion Criteria
1. Positive skin-test reaction to penicillin antigen and ceftriaxone antigen
2. History of penicillin and ceftriaxone allergy
3. Patients who have received any other antibiotics before initiation of treatment
4. Patients with Late latent syphilis and Tertiary syphilis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serological response as defined as a four fold decrease in the initial RPR titre within 6 months of treatmentTimepoint: Serological response as defined as a four fold decrease in the initial RPR titre within 6 months of treatment
- Secondary Outcome Measures
Name Time Method Comparing the time taken for RPR to fall in both groups and to monitor for Adverse events if any in both groupsTimepoint: 6 months