JPRN-jRCTs031180070已完成未知
The clinical trial to examine the densities of AMPA receptors in epilepsy patients with [11C]K-2
Miyazaki Tomoyuki0 个研究点目标入组 34 人开始时间: 2018年12月28日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 34
研究概览
简要总结
The primary endpoint of the study showed that there were regions of higher AMPA receptor density in PVC processed images compared to healthy subjects in both the partial and generalized seizure groups. On the other hand, no significant trend was observed in the images without PVC treatment. We also investigated the areas where EEG activity correlated with AMPA receptors and FDG-PET imaging values, as well as the areas where IQ correlated with AMPA receptors and FDG-PET imaging values. In addition, there wer
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 < 60age old（—）
- 性别
- Male
入选标准
- •1. Patients diagnosed with epilepsy on the basis of ILAE criteria
- •2. Patients who have seizures 12months prior to registration
- •3. Patients without neurosurgery in the past
- •4. Patients who are over 20 years and below 60 years
- •5. Patients who can consent to this study by oneself
排除标准
- •1. Patients who have experienced the electric stimulation therapy
- •2. Patients who have severe renal dysfunction (Serum Cre>1.5)
- •3. Patients who have severe liver dysfunction (AST and ALT>150)
- •4. Patients who have severe cardiovascular disorder
- •5. Patients who have tatoo
- •6. Claustrophobic patients
- •7. Patients who can not agree with contraception during 7days after [11C]K-2 PET
- •8. Patients who take Perampanel or Topiramate(within 1month before this registration)
- •9.Patients who underwent nuclear medicine examination within
- •1 week before this registration
- •10.Patients who underwent other clinical trials using unapproved
- •nuclear medicine examination within 6 months before this
- •registration
- •11.Patients who underwent other clinical trial within 12 weeks before this registration
- •12.Patients whom study doctors consider inappropriate
研究者
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