A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
- Conditions
- Heart Failure
- Interventions
- Registration Number
- NCT06935370
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before the study. The purpose of this study is to find out whether a medicine called vicadrostat, in combination with another medicine called empagliflozin, helps people with chronic heart failure.
In this study, participants are put into 2 groups randomly. Participants have an equal chance of being in either group. One group takes vicadrostat and empagliflozin tablets, and the other group takes placebo and empagliflozin tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants take the study medicines as tablets once a day for between 1 and about 3.5 years. During this time, they can continue their regular treatment for heart failure.
Participants can stay in the study as long as they benefit from treatment and can tolerate it, for a maximum of about 3.5 years. During this time, they visit the study site regularly. The exact number of visits is different for each participant, depending on how long they stay in the study. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being. The doctors document when participants experience worsening of their heart failure symptoms, must go to hospital due to heart failure, or die during the study. The time until these events are observed is compared between the treatment groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 4200
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description vicadrostat + empagliflozin treatment group Vicadrostat - vicadrostat + empagliflozin treatment group Empagliflozin - Placebo to vicadrostat + empagliflozin treatment group Empagliflozin - Placebo to vicadrostat + empagliflozin treatment group Placebo matching vicadrostat -
- Primary Outcome Measures
Name Time Method Time to first event of Cardiovascular (CV) death, or Hospitalisation for heart failure (HHF), or Urgent heart failure (HF) visit up to 43 months
- Secondary Outcome Measures
Name Time Method Key secondary endpoint: Time to first event of cardiovascular death or hospitalisation for heart failure up to 43 months Key secondary endpoint: Occurrences of hospitalisation for heart failure (first and recurrent) up to 43 months Key secondary endpoint: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire-Total Symptom Score (KCCQ-TSS) at Week 32 at baseline, at week 32 The KCCQ is a participant reported outcome. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in people with heart failure.
The symptom frequency and symptom burden domains are merged into a total symptom score (TSS).
Scores are transformed to a range of 0-100, in which higher scores reflect better health status.Key secondary endpoint: Time to cardiovascular death up to 43 months Key secondary endpoint: Time to all-cause mortality up to 43 months Time to first hospitalisation for heart failure up to 43 months Time to first occurrence of death from kidney failure, chronic dialysis* or renal transplant or onset of sustained reduction of ≥ 50% estimated glomerular filtration rate (eGFR) or onset of sustained eGFR (CKD-EPI)cr < 10 mL/min/1.73 m² from baseline, up to 43 months \* Chronic dialysis is defined as dialysis continuing for at least 30 days. For this composite renal endpoint the Chronic Kidney Disease Epidemiology Collaboration creatinine ((CKD-EPI)cr) equation is used.
Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire- Clinical Summary Score (KCCQ-CSS) at Week 32 at baseline, at week 32 The KCCQ is a participant reported outcome. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in people with heart failure.
The Clinical Summary Score (CSS) of the KCCQ provides a measure of symptoms and physical limitations associated with heart failure.
Scores are transformed to a range of 0-100, in which higher scores reflect better health status.Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire-Total Symptom Score (KCCQ-TSS) at Week 52 at baseline, at week 52 The KCCQ is a participant reported outcome. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in people with heart failure.
The symptom frequency and symptom burden domains are merged into a total symptom score (TSS).
Scores are transformed to a range of 0-100, in which higher scores reflect better health status.Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire- Overall Summary Score (KCCQ-OSS) at Week 32 at baseline, at week 32 The KCCQ is a participant reported outcome. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in people with heart failure.
In the KCCQ, an overall summary score (OSS) can be derived from the physical function, symptom (frequency and severity), social function and quality of life domains.
Scores are transformed to a range of 0-100, in which higher scores reflect better health status.Absolute change from baseline in KCCQ-OSS at Week 52 at baseline, at week 52 The KCCQ is a participant reported outcome. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in people with heart failure.
In the KCCQ, an overall summary score (OSS) can be derived from the physical function, symptom (frequency and severity), social function and quality of life domains.
Scores are transformed to a range of 0-100, in which higher scores reflect better health status.Absolute change from baseline in systolic blood pressure (SBP) [mmHg] at Week 32 in participants with baseline SBP ≥ 130 mmHg at baseline, at week 32 Absolute change from baseline in diastolic blood pressure (DBP) [mmHg] at Week 32 in participants with baseline DBP ≥ 80 mmHg at baseline, at week 32
Related Research Topics
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Trial Locations
- Locations (348)
Klinikum Worms gGmbH
🇩🇪Worms, Germany
Instituto Médico DAMIC S.R.L.
🇦🇷Cordoba, Argentina
Centro Medico Luquez
🇦🇷Cordoba, Argentina
Helios CR Inc - Fort Worth
🇺🇸Fort Worth, Texas, United States
Alliance for Multispecialty Research, LLC
🇺🇸Mobile, Alabama, United States
Orange County Research Center
🇺🇸Lake Forest, California, United States
Cardiology Associates Research Co.
🇺🇸Daytona Beach, Florida, United States
Velocity Clinical Research-Hallandale Beach-67888
🇺🇸Hallandale Beach, Florida, United States
East Coast Institute For Research, LLC
🇺🇸Jacksonville, Florida, United States
Peace River Cardiovascular Center
🇺🇸Port Charlotte, Florida, United States
Cardiology Partners Clinical Research Institute
🇺🇸Wellington, Florida, United States
Cozy Research LLC
🇺🇸Wesley Chapel, Florida, United States
Clinical Site Partners, LLC
🇺🇸Winter Park, Florida, United States
Columbus Regional Research Institute
🇺🇸Columbus, Georgia, United States
NSC Research Inc
🇺🇸Johns Creek, Georgia, United States
Indiana Medical Research Institute
🇺🇸Merrillville, Indiana, United States
Cardiovascular Research of Northwest Indiana, LLC
🇺🇸Munster, Indiana, United States
North Kansas City Hospital
🇺🇸Kansas City, Missouri, United States
Advanced Heart Care, LLC
🇺🇸Bridgewater, New Jersey, United States
Garden State Heart Care, PC
🇺🇸Manalapan, New Jersey, United States
K and R Research LLC
🇺🇸Marion, Ohio, United States
Bon Secours Medical Group Greenville Specialty Care, LLC
🇺🇸Greenville, South Carolina, United States
Monument Health
🇺🇸Rapid City, South Dakota, United States
Pharmatex Research
🇺🇸Amarillo, Texas, United States
Amarillo Heart Clinical Research Institute, Incorporated
🇺🇸Amarillo, Texas, United States
Texas Health Research and Education Institute
🇺🇸Dallas, Texas, United States
Southwest Family Medicine Associates
🇺🇸Dallas, Texas, United States
Sanatorio Parque
🇦🇷Rosario, Argentina
North Texas Research Associates
🇺🇸McKinney, Texas, United States
Texas Institute Of Cardiology
🇺🇸McKinney, Texas, United States
Inst de Inv Clinicas-Bahia Blanca
🇦🇷Bahia Blanca, Argentina
Hospital Regional de Bahia Blanca
🇦🇷Bahia Blanca, Argentina
CINME - Centro De Investigaciones Metabolicas
🇦🇷Caba, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Fundacion Favaloro
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Mautalen- Salud e Investigacion
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Centro Medico Dra Laura Maffei
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Glenny Corp. S.A. Bioclinica Argentina
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Centro de Investigaciones y Prevencion Cardiovascular CIPREC
🇦🇷Ciudad Autonoma de Buenos Aires, Argentina
Sanatorio Allende
🇦🇷Cordoba, Argentina
Clinica Privada Colombo- Fundacion Clinica Colombo
🇦🇷Cordoba, Argentina
Clinica Coronel Suárez
🇦🇷Coronel Suarez, Argentina
Well Medica
🇦🇷Córdoba, Argentina
Hospital Italiano de La Plata
🇦🇷La Plata, Argentina
Centro de Investigaciones Medicas Mar del Plata
🇦🇷Mar del Plata, Argentina
Hospital Universitario Austral
🇦🇷Pilar, Argentina
Instituto Medico CER
🇦🇷Quilmes, Argentina
Instituto de Investigaciones Clínicas de Quilmes
🇦🇷Quilmes, Argentina
DIM Clinica Privada
🇦🇷Ramos Mejía, Argentina
INECO Neurociencias Oroño
🇦🇷Rosario, Argentina
Instituto de Investigaciones Clinicas de Rosario
🇦🇷Rosario, Argentina
Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica
🇦🇷Rosario, Argentina
Instituto CAICI
🇦🇷Rosario, Argentina
Investigaciones Clinicas Salta (ICSAL)
🇦🇷Salta, Argentina
Centro Cardiovascular Salta
🇦🇷Salta, Argentina
Corporacion Medica de Gral. San Martin S.A.
🇦🇷San Martin, Argentina
Investigaciones Clinicas Tucuman
🇦🇷San Miguel de Tucuman, Argentina
Instituto de Cardiologia SRL
🇦🇷San Miguel de Tucuman, Argentina
Centro Modelo de Cardiologia
🇦🇷San Miguel de Tucuman, Argentina
Clinica Mayo
🇦🇷San Miguel de Tucuman, Argentina
Instituto de Investigaciones Clinicas San Nicolas
🇦🇷San Nicolas, Argentina
Centro de Investigaciones Clinicas Baigorria
🇦🇷Santa Fe, Argentina
Hospital "Dr. José Maria Cullen"
🇦🇷Santa Fe, Argentina
Centro de Investigaciones Clínicas del Litoral
🇦🇷Santa Fe, Argentina
CEMEDIC - Centro de Especialidades Medicas
🇦🇷Villa Luro, Argentina
AZ Sint-Blasius
🇧🇪Dendermonde, Belgium
Ziekenhuis Oost-Limburg - Campus Sint-Jan
🇧🇪Genk, Belgium
AZ Sint-Lucas
🇧🇪Gent, Belgium
Grand Hôpital de Charleroi - Les Viviers
🇧🇪Gilly, Belgium
Kortrijk - HOSP AZ Groeninge Kennedylaan
🇧🇪Kortrijk, Belgium
La Louvière - UNIV CHU Tivoli
🇧🇪La Louvière, Belgium
Liège - HOSP CHR de la Citadelle
🇧🇪Liège, Belgium
Hospital Felicio Rocho
🇧🇷Belo Horizonte, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
🇧🇷Belo Horizonte, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda.
🇧🇷Brasília, Brazil
Hospital DF Star
🇧🇷Brasília, Brazil
CECAP - Centro de Cardiologia Clínica
🇧🇷Brasília, Brazil
Hospital Angelina Caron
🇧🇷Campina Grande do Sul, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
🇧🇷Campinas, Brazil
Hospital PUC-Campinas
🇧🇷Campinas, Brazil
I9 Pesquisas Clinicas - Loema Instituto de Pesquisa Clínica e Consultores SS Ltda
🇧🇷Campinas, Brazil
Hospital do Rocio
🇧🇷Campo Largo, Brazil
Fundacao Universidade de Caxias do Sul
🇧🇷Caxias do Sul, Brazil
PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
🇧🇷Curitiba, Brazil
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
🇧🇷Goiania, Brazil
Via Medica
🇧🇷Goiânia, Brazil
ICM - Instituto do Coracao de Marilia
🇧🇷Marília, Brazil
Hospital Vera Cruz
🇧🇷Minas Gerais, Brazil
Instituto Atena de Pesquisa Clinica
🇧🇷Natal, Brazil
Instituto Mederi de Pesquisa e Saude
🇧🇷Passo Fundo, Brazil
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Universidade Federal do Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Hospital Mae de Deus
🇧🇷Porto Alegre, Brazil
Clinicor Clínica Cardiológica LTDA/ Cardio Prime - CENTRO AVANÇADO DE PESQUISA, ESTUDOS E DIAGNÓSTICO (CAPED)
🇧🇷Ribeirão Preto, Brazil
Instituto Brasil de Pesquisa Clinica (IBPClin)
🇧🇷Rio de Janeiro, Brazil
Ruschel Medicina e Pesquisa Clínica
🇧🇷Rio de Janeiro, Brazil
Instituto D'Or Pesquisa e Ensino - Rio de Janeiro
🇧🇷Rio de Janeiro, Brazil
Hospital Cardio Pulmonar
🇧🇷Salvador, Brazil
Pesquisare
🇧🇷Santo Andre, Brazil
Praxis Pesquisa Medica
🇧🇷Santo Andre, Brazil
Cpquali Pesquisa Clinica Ltda
🇧🇷Sao Paulo, Brazil
Centro de Pesquisa Clinica - CPCLIN
🇧🇷Sao Paulo, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
🇧🇷Sao Paulo, Brazil
Instituto Domingo Braile
🇧🇷São José do Rio Preto, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto
🇧🇷São José do Rio Preto, Brazil
CIPES - Centro Internacional de Pesquisa Clínica
🇧🇷São José dos Campos, Brazil
Eurolatino Pesquisas Médicas Ltda.
🇧🇷Uberlandia, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória
🇧🇷Vitória, Brazil
Cambridge Cardiac Care Centre
🇨🇦Cambridge, Ontario, Canada
Premier Clinical Trial Network
🇨🇦Hamilton, Ontario, Canada
Elevate Clinical Research - KMH Hamilton
🇨🇦Kitchener, Ontario, Canada
KMH Cardiology Centres (Mississauga)
🇨🇦Mississauga, Ontario, Canada
Oakville Trafalgar Memorial Hospital
🇨🇦Oakville, Ontario, Canada
James Cha, MD
🇨🇦Oshawa, Ontario, Canada
Kawartha Cardiology Clinical Trials
🇨🇦Peterborough, Ontario, Canada
CardioQuest Research Centre
🇨🇦Sarnia, Ontario, Canada
Niagara Health System - St. Catharines Site
🇨🇦St. Catharines, Ontario, Canada
Health Sciences North
🇨🇦Sudbury, Ontario, Canada
ViaCar Recherches Cliniques Inc. (Brossard)
🇨🇦Brossard, Quebec, Canada
Diex Recherche (Trois-Rivieres)
🇨🇦Trois-Rivieres, Quebec, Canada
CardioVasc HR Inc.
🇨🇦St. Jean sur Richelieu, Canada
Beijing AnZhen Hospital
🇨🇳Beijing, China
The First Hospital of Jilin University
🇨🇳Changchun, China
China-Japan Union Hospital of Jilin University
🇨🇳Changchun, China
Changde Second People's Hospital
🇨🇳Changde City, China
The Third Hospital of Changsha
🇨🇳Changsha, China
People's Hospital of Sichuan Province
🇨🇳Chengdu, China
Chenzhou No.1 people's Hospital
🇨🇳Chenzhou, China
Second Affiliated Hospital Chongqing Medical University
🇨🇳Chongqing, China
Affiliated Zhongshan Hospital of Dalian University
🇨🇳Dalian, China
People's Hospital of Deyang City
🇨🇳Deyang, China
The First People's Hospital of Foshan
🇨🇳Foshan, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
🇨🇳Guangzhou, China
Guangdong Provincial People's Hospital
🇨🇳Guangzhou, China
Third Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, China
The Affiliated Panyu Central Hospital of Guangzhou Medical University
🇨🇳Guangzhou, China
Guizhou People's Hospital
🇨🇳Guiyang, China
Jiangmen Central Hospital
🇨🇳Jiangmen, China
Center Hospital of Jinan
🇨🇳Jinan, China
The Second Affiliated Hospital of Lanzhou Medical University
🇨🇳Lanzhou, China
Linfen Central Hospital
🇨🇳Linfen, China
The First Affiliated Hospital of Henan University of Science and Technology
🇨🇳Luoyang, China
Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital
🇨🇳Nanchang, China
Nanjing Jiangning Hospital
🇨🇳Nanjing, China
The First Affiliated Hospital of Guangxi Medical University
🇨🇳Nanning, China
Nanyang Second General Hospital
🇨🇳Nanyang, China
Panjin Liao Oil Gem Flower Hospital
🇨🇳Panjin, China
Zhongshan Hospital Affiliated to Fudan University
🇨🇳Shanghai, China
Tongren hospital, Shanghai Jiaotong University School of Medicine
🇨🇳Shanghai, China
Shanghai General Hospital
🇨🇳Shanghai, China
People's Hospital of Liaoning Province
🇨🇳Shenyang, China
Shenzhen People's Hospital
🇨🇳Shenzhen, China
Hubei Province Zhongshan Hospital
🇨🇳Wuhan, China
The People's Hospital Of Xuancheng City
🇨🇳Xuancheng, China
Yuncheng Central Hospital
🇨🇳Yuncheng, China
The First Affiliated Hospital of Hebei North University
🇨🇳Zhangjiakoou, China
The First Affiliated Hospital of Zhengzhou University
🇨🇳Zhengzhou, China
Affiliated Hospital of Jiangsu University
🇨🇳Zhenjiang, China
Cardiomet CEQUIN S.A.S
🇨🇴Armenia, Colombia
Centro de Investigacion Medico Asistencial S.A.S
🇨🇴Barranquilla, Colombia
Corazon IPS S.A.S.
🇨🇴Barranquilla, Colombia
Fundacion Santa Fe de Bogota
🇨🇴Bogota, Colombia
Administradora Country S.A.S.
🇨🇴Bogota, Colombia
Fundacion Hospital Infantil Universitario de San José
🇨🇴Bogota, Colombia
IPS Centro Medico Julián Coronel S.A.
🇨🇴Cali, Colombia
Centro de Diagnostico Cardiologico para la Investigacion Bio
🇨🇴Cartagena, Colombia
Asociacion IPS Medicos Internistas de Caldas
🇨🇴Manizales, Colombia
T Y C Inversiones S A S Grupsalud
🇨🇴Santa Marta, Colombia
MUDr. Hana Burianova
🇨🇿Bilovec, Czechia
Medicus Services Ltd.
🇨🇿Brandys nad Labem, Czechia
Interni Ordinace s.r.o.
🇨🇿Brandýs nad Labem, Czechia
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
🇨🇿Brno, Czechia
Fakultni nemocnice u sv. Anny v Brne
🇨🇿Brno, Czechia
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
🇨🇿Chrudim, Czechia
EDUMED s.r.o.
🇨🇿Jaromer, Czechia
MUDr Petra Maskova PhD
🇨🇿Litovel, Czechia
KardioBusak s.r.o.
🇨🇿Louny, Czechia
InterKardioML s.r.o.
🇨🇿Marianske Lazne, Czechia
MUDr. Zdenek Vomacka kardiologie a interna s.r.o.
🇨🇿Olomouc, Czechia
MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna
🇨🇿Praha 10, Czechia
Kardiologie Vinohrady s r o
🇨🇿Praha 1, Czechia
Institute For Clinical And Experimental Medicine
🇨🇿Praha 4, Czechia
University Hospital Motol
🇨🇿Praha 5, Czechia
Fakultni Thomayerova nemocnice
🇨🇿Praha, Czechia
Hospital Slany, Internal Department
🇨🇿Slany, Czechia
Kardiologicka ambulance MUDr. Ferkl s.r.o.
🇨🇿Trutnov, Czechia
Clinical Trials Services s.r.o
🇨🇿Uherske Hradiste, Czechia
Sygehus SonderJylland/ Sonderborg
🇩🇰Aabenraa, Denmark
Bispebjerg og Frederiksberg Hospital
🇩🇰Copenhagen NV, Denmark
Amager-Hvidovre Hospital
🇩🇰Copenhagen S, Denmark
Rigshospitalet
🇩🇰Copenhagen, Denmark
Herlev and Gentofte Hospital
🇩🇰Herlev, Denmark
Holbæk Sygehus
🇩🇰Holbæk, Denmark
Hvidovre Hospital
🇩🇰Hvidovre, Denmark
Sjællands Universitetshospital
🇩🇰Roskilde, Denmark
Slagelse Sygehus
🇩🇰Slagelse, Denmark
SLK-Kliniken Heilbronn GmbH
🇩🇪Bad Friedrichshall, Germany
Dres. Haas/Kirschner/Wagner
🇩🇪Bamberg, Germany
GFO Kliniken Bonn
🇩🇪Bonn, Germany
Universitätsklinikum Bonn AöR
🇩🇪Bonn, Germany
SANA Kliniken Oberfranken Coburg GmbH
🇩🇪Coburg, Germany
Helios Klinikum Erfurt
🇩🇪Erfurt, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitätsklinikum Jena
🇩🇪Jena, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
🇩🇪Langen, Germany
Praxis Oedeme
🇩🇪Lüneburg, Germany
Marienhaus Klinikum St. Elisabeth, Neuwied
🇩🇪Neuwied, Germany
Dr. Andreas Wilke Dr. Andrej Malazhavy und Detelin Lalev Denchev Fachaerzte Innere Medizin und Kardiologie Partnerschaft
🇩🇪Papenburg, Germany
Universitätsklinikum Regensburg
🇩🇪Regensburg, Germany
Kardiologische Praxis, Wermsdorf
🇩🇪Wermsdorf, Germany
Belgyogyaszati es Kardiologiai Maganrendelo
🇭🇺Bekescsaba, Hungary
Buda Hospital of the Hospitaller Order of Saint John of God
🇭🇺Budapest, Hungary
Obudai Egeszegugyi Centrum
🇭🇺Budapest, Hungary
Belvaros-Lipotvaros Egeszsegugyi Szolgalat
🇭🇺Budapest, Hungary
Gottsegen National Cardiovascular Center
🇭🇺Budapest, Hungary
Semmelweis University
🇭🇺Budapest, Hungary
Privat Doktor Egeszseguegyi Szolgaltato Zrt.
🇭🇺Budapest, Hungary
Zugloi Egeszsegugyi Szolgalat
🇭🇺Budapest, Hungary
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
🇭🇺Miskolc, Hungary
IPR Hungary Kft.
🇭🇺Miskolc, Hungary
TaNa Med Kft.
🇭🇺Mosonmagyarovar, Hungary
Coromed-Smo Kft.
🇭🇺Pecs, Hungary
Tolna Varmegyei Balassa Janos Korhaz
🇭🇺Szekszard, Hungary
Belvarosi Egeszseghaz Kft.
🇭🇺Zalaegerszeg, Hungary
S.P. Medical College & Associated Group of Hospitals
🇮🇳Bikaner, India
Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH
🇮🇳Chennai, India
Apollo Hospitals
🇮🇳Chennai, India
Medanta-The Medicity
🇮🇳Gurgaon, India
IPGMER and SSKM Hospital
🇮🇳Kolkata, India
King George Hospital
🇮🇳Vishakhapatnam, India
Humanitas Gavazzeni
🇮🇹Bergamo, Italy
ASST Papa Giovanni XXIII
🇮🇹Bergamo, Italy
Az.Osp. Universitaria "Ospedali Riuniti"
🇮🇹Foggia, Italy
Azienda Ospedaliera Universitaria "Federico II"
🇮🇹Napoli, Italy
Fondazione IRCCS Policlinico S. Matteo
🇮🇹Pavia, Italy
Azienda Ospedaliera Universitaria Pisana
🇮🇹Pisa, Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
🇮🇹Roma, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
Inje University Busan Paik Hospital
🇰🇷Busan, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Pusan National University Yangsan Hospital
🇰🇷Busan, Korea, Republic of
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju-si, Gangwon State, Korea, Republic of
Hospital Cardiologica Aguascalientes
🇲🇽Aguascalientes, Mexico
Centro Especializado de Investigación Medical Group Culiacan
🇲🇽Culiacan, Mexico
Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
🇲🇽Culiacan, Mexico
Cardiologia Clinica e Intervencionista
🇲🇽Guadalajara, Mexico
Proactive CR Mexico S.A. de C.V.
🇲🇽Irapuato, Mexico
Centro de Estudios de Alta Especialidad de Sinaloa CEAES
🇲🇽Mazatlan, Mexico
Cardiolink Clin Trials S.C.
🇲🇽Monterrey, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
🇲🇽Monterrey, Mexico
Clinstile S.A. de C.V.
🇲🇽México, Mexico
Centro de Estudios Clinicos de Queretaro S.C
🇲🇽Queretaro, Mexico
Centro de Investigacion Cardiovascular y Metabolica
🇲🇽Tijuana, Mexico
CIMAB S.A. de C.V.
🇲🇽Torreon, Mexico
Jeroen Bosch Ziekenhuis-Hertogenbosch
🇳🇱's-HERTOGENBOSCH, Netherlands
Amsterdam University Medical Center
🇳🇱Amsterdam, Netherlands
Catharina Ziekenhuis
🇳🇱Eindhoven, Netherlands
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Maastricht University
🇳🇱Maastricht, Netherlands
St. Antonius ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
Isala Zwolle
🇳🇱Zwolle, Netherlands
American Heart Of Poland Sp. Z O.O.
🇵🇱Bielsko-Biala, Poland
INTERCORE Medical Center
🇵🇱Bydgoszcz, Poland
Pratia Bydgoszcz Clinical Research Site
🇵🇱Bydgoszcz, Poland
NZOZ Medical Center KERmed
🇵🇱Bydgoszcz, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
🇵🇱Gdansk, Poland
Medical Centre Pratia Gdynia
🇵🇱Gdynia, Poland
Specjalistyczna Praktyka Lekarska Ewa Mirek-Bryniarska
🇵🇱Krakow, Poland
Linden Sp. z o.o. sp.k.
🇵🇱Kraków, Poland
Pratia MCM Krakow
🇵🇱Kraków, Poland
Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j.
🇵🇱Legnica, Poland
Santa Sp. z o.o. Santa Familia PTG Lodz
🇵🇱Lodz, Poland
Velocity Lublin
🇵🇱Lublin, Poland
Zanamed Medical Clinic Sp. z o.o.
🇵🇱Lublin, Poland
NZOZ HEUREKA, Piaseczno
🇵🇱Piaseczno, Poland
CBK Med Clinic SP Z O O
🇵🇱Plock, Poland
MEDYK Medical Center
🇵🇱Rzeszow, Poland
Lukmed Lukasz Wozniak
🇵🇱Siedlce, Poland
Velocity Skierniewice Sp. z o.o
🇵🇱Skierniewice, Poland
Centrum Medyczne Pratia Poznan
🇵🇱Skórzewo, Poland
Velocity Staszow
🇵🇱Staszow, Poland
ETG Warszawa
🇵🇱Warsaw, Poland
Balsammedica Sp. z o. o.
🇵🇱Warszawa, Poland
MTZ Clinical Research Powered by Pratia
🇵🇱Warszawa, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ
🇵🇱Wroclaw, Poland
Sedimed Sp. z o.o.
🇵🇱Wroclaw, Poland
NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
🇵🇱Zarow, Poland
King AbdulAziz University Hospital
🇸🇦Al Ahsa, Saudi Arabia
King Fahad Specialist Hospital - Research Center
🇸🇦Dammam, Saudi Arabia
King Faisal Specialist Hospital and Research Center
🇸🇦Riyadh, Saudi Arabia
King Fahad Medical City
🇸🇦Riyadh, Saudi Arabia
Clinical Center " Dr Dragisa Misovic Dedinje"
🇷🇸Belgrade, Serbia
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
University Clinical Center of Kragujevac
🇷🇸Kragujevac, Serbia
Institute for Treatment and Rehabilitation, Niska Banja
🇷🇸Niska Banja, Serbia
University Clinical Center Nis
🇷🇸Nis, Serbia
General Hospital Pancevo
🇷🇸Pancevo, Serbia
General Hospital Sveti Luka
🇷🇸Smederevo, Serbia
Institute of Cardiovascular Diseases of Vojvodine
🇷🇸Sremska Kamenica, Serbia
Health Centre Zajecar
🇷🇸Zajecar, Serbia
Kardiointerna s r o
🇸🇰Banska Bystrica, Slovakia
Stredoslovensky Ustav Srdcovych A Cievnych Chorob A S
🇸🇰Banska Bystrica, Slovakia
Alian s.r.o.
🇸🇰Bardejov, Slovakia
Cliniq s.r.o.
🇸🇰Bratislava, Slovakia
Nemocnica AGEL Zvolen a s
🇸🇰Bratislava, Slovakia
Premedix Clinic
🇸🇰Bratislava, Slovakia
Nemocnica s poliklinikou Brezno n.o.
🇸🇰Brezno, Slovakia
Medical Group Kosice s.r.o
🇸🇰Kosice, Slovakia
KARDIO R s r o
🇸🇰Kosice, Slovakia
CARDIO D&R spol.s.r.o. Kosice
🇸🇰Kosice, Slovakia
KARDIO 1 s.r.o.
🇸🇰Lucenec, Slovakia
Kardiomed s.r.o.
🇸🇰Lucenec, Slovakia
Kvc-Kardiovaskularne Centrum
🇸🇰Martin, Slovakia
Cardiocenter Nitra, s.r.o
🇸🇰Nitra, Slovakia
Cardioamb s.r.o
🇸🇰Nove Zamky, Slovakia
Hospital Vall Hebron
🇪🇸Barcelona, Spain
Hospital Clínic de Barcelona
🇪🇸Barcelona, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Hospital La Paz
🇪🇸Madrid, Spain
Hospital Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital Virgen del Camino
🇪🇸Sanlucar de Barrameda, Spain
Complexo Hospitalario Universitario De Santiago
🇪🇸Santiago de Compostela, Spain
Pratia ES Hospital Universitario de Torrejon
🇪🇸Torrejón de Ardoz, Spain
Hospital Clínico de Valencia
🇪🇸Valencia, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Politècnic La Fe
🇪🇸Valencia, Spain
Hospital Virgen de las Montañas, Villamartin
🇪🇸Villamartin, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳Kaohsiung, Taiwan
E-Da Hospital
🇨🇳Kaohsiung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
Taipei Medical University Hospital
🇨🇳Taipei City, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Tri-Service General Hospital
🇨🇳Taipei, Taiwan
Chang-Hua Christian Hospital
🇨🇳Taipei, Taiwan
Southmead Hospital
🇬🇧Bristol, United Kingdom
St Richard's Hospital
🇬🇧Chichester, United Kingdom
Royal Devon and Exeter Hospital, Wonford
🇬🇧Exeter, United Kingdom
Calderdale Royal Hospital
🇬🇧Halifax, United Kingdom
St Bartholomew's Hospital
🇬🇧London, United Kingdom