NCT02175940已完成不适用
Effect of Intravitreal Ranibizumab Injection on Aqueous Humor Concentrations of Vascular Endothelial Growth Factor and Pigment Epithelium-derived Factor in Patients With Myopic Choroidal Neovascularization.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- vascular endothelial growth factor (VEGF) aqueous levels
研究概览
简要总结
This was a prospective, case-control study investigating aqueous levels of VEGF and PEDF in eyes with mCNV treated with IVB.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pathologic myopia, defined as spherical equivalent >6 diopters and axial length >26 mm
- •posterior pole myopic retinal changes (posterior staphyloma, chorioretinal atrophy, papillary crescent);
- •fluorescein angiography, indocyanine green angiography and optical coherence tomography detection of the subfoveal or juxtafoveal choroidal neovascularization
- •clear ocular media;
排除标准
- •previous treatment for choroidal neovascularization, including the previous intravitreal drug injection or PDT
- •presence of other maculopathy as diabetic retinopathy or retinal vascular occlusion
- •history of recent myocardial infarction or other thromboembolic events
- •ongoing uncontrolled hypertension or glaucoma
- •refractive media opacities
- •previous eye surgery
结局指标
主要结局
vascular endothelial growth factor (VEGF) aqueous levels
时间窗: 2 months
VEGF aqueous levels before and after intravitreal ranibizumab
pigment epithelium-derived factor (PEDF) aqueous levels
时间窗: 2 months
PEDF aqueous levels before and after intravitreal ranibizumab
次要结局
- best-corrected visual acuity(2 months)
- central retinal thickness(2 months)
研究者
Andrea Russo
MD, PhD Researcher
Università degli Studi di Brescia
研究点 (1)
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