The Use of Biomarkers for Predicting Mortality in Patients With Suspected Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- 28-day mortality
研究概览
简要总结
This retrospective study aimes to analyze the association of a number of routinely performed biomarkers with mortality in patients admitted to ICU with suspected sepsis.
The study includes patients >18 years of age, who had been admitted to the ICU with suspected sepsis. At ICU admission, baseline levels of PCT, CRP, albumin and lactate as well as WBC, neutrophil and lymphocyte counts will recorded.
详细描述
This study aimes to investigate the association of a number of biomarkers with 28-day mortality of patients admitted to the ICU with suspected sepsis, which included C-reactive protein (CRP), procalcitonin (PCT), WBC count, neutrophil count, lymphocyte count, albumin and lactate.
Data will obtained from hospital electronic medical records. Data includes age, sex, duration of ICU stay, origin of infection (urinary, abdominal, pulmonary, soft tissue, central nervous system, catheter-related, mixed, others) and comorbidities (hypertension, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure, heart failure, coronary artery disease, malignancies, others). Whether patients were admitted to the ICU following a scheduled surgery or emergency surgery will also recorded.
At admission, baseline levels of PCT, CRP, albumin and lactate as well as WBC, neutrophil and lymphocyte counts will recorded.
The primary outcome is 28-day mortality. For patients with multiple episodes requiring ICU admission, only the most recent episode will taken into consideration.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>18 years of age
- •admission to the ICU with suspected sepsis
排除标准
- •ICU admission following cardiopulmonary resuscitation or cardiac surgery
- •Having a positive test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
- •Interruption of the treatment process because of transfer to another healthcare facility
结局指标
主要结局
28-day mortality
时间窗: 28 days
mortality within 28 days after intensive care admission
次要结局
未报告次要终点