A Phase IV, Randomized, Double Blind, Placebo Controlled, Single-center Study of the Impact of Topical Steroids on Narrow Band UVB (Ultraviolet B) and Dithranol Combination Treatment of Psoriasis (DIPSO)
Overview
- Phase
- Phase 4
- Intervention
- Steroid active treatment
- Conditions
- Psoriasis
- Sponsor
- University of Zurich
- Locations
- 1
- Primary Endpoint
- Relapse 50% PASI after treatment, time to PASI 75% on treatment
- Status
- Withdrawn
- Last Updated
- 7 years ago
Overview
Brief Summary
Objective(s):
(i) To assess the effect of adjunctive topical steroids in the combined treatment with UVBnb and dithranol on the remission time after therapy till a relapse of psoriasis defined as 50% loss of PASI (Psoriasis Area and Severity Index) improvement obtained through the antecedent treatment.
(ii) To assess the impact of adjuvant topical steroids in the combined treatment with UVBnb and dithranol on the clearing time of psoriasis lesions under therapy (PASI 75).
- Trial with medicinal product
Detailed Description
(i) To assess the effect of adjunctive topical steroids in the combined treatment with UVBnb and dithranol on the remission time after therapy till a relapse of psoriasis defined as 50% loss of PASI (Psoriasis Area and Severity Index) improvement obtained through the antecedent treatment. (ii) To assess the impact of adjuvant topical steroids in the combined treatment with UVBnb and dithranol on the clearing time of psoriasis lesions under therapy (PASI 75). * Trial with medicinal product
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
Steroid active treatment
Triamcinolone acetonide 0.1% in unguentum leniens topically
Intervention: Steroid active treatment
Vehicle
unguentum leniens topically
Intervention: Steroid active treatment
Outcomes
Primary Outcomes
Relapse 50% PASI after treatment, time to PASI 75% on treatment
Time Frame: 2 years
Relapse 50% PASI after treatment, time to PASI 75% on treatment