Physical Activity Immediately After Acute Cerebral Ischemia

Not Applicable

• Conditions: Acute Ischemic Stroke; Physical Activity; Accelerometer
• Interventions: Behavioral: physical activity 15 minutes/day; Behavioral: physical activity, 2 x 30 minutes/day

• Registration Number: NCT01594190
• Lead Sponsor: Hillerod Hospital, Denmark

Brief Summary

Stroke is the leading cause of adult disability in Europe and United States and the second leading cause of death worldwide and affects more than 10,000 Danes each year.

Studies in a late and stationary phase after stroke have shown that physical rehabilitation is of great importance for survival and physical ability of these patients, however many studies show that patients lie or sit next to their bed under hospitalization for more than 88.5 % of the daily hours. Physical activity in stroke patients has never previously been measured immediately after debut of symptoms; furthermore there is no knowledge about the optimal dose of physical rehabilitation for these patients.

Accelerometers, small measuring devices, are a relatively new way to measure physical activity precisely, and hence it is possible to obtain an objective measure of how active stroke patients are in the first week after admission. The accelerometers measure a variable voltage, depending on the range and intensity of movement. They can measure movement dependent of the placement of the accelerometer, for instance over the hip, arm or leg. Studies confirm their reliability, even in patients with abnormal gait, such as stroke patients.

Another approach of studying the effects of physical activity and rehabilitation is through the examination of biomarkers. Studies have shown that biomarkers released during physical activity can inhibit biomarkers released after tissue injury in the brain, as seen after stroke. These brain biomarkers cause further damage and studies show that the higher the levels, the higher the damage. It is therefore obvious to examine whether physical activity rehabilitation can down regulate this destructive process in patients with stroke.

Clarification of the optimal dose of physical activity in stroke patients immediately after debut of symptoms and examination of both the biochemical aspects of physical rehabilitation as well as the optimal dose of physical rehabilitation is of great importance for many patients, their relatives as well as of a great socioeconomic importance.

The purpose of the project is to investigate which dose (15 vs. 2 x 30 minutes) of physical activity on a weight-bearing treadmill in the first 5 days after admission after an ischemic stroke, gives patients the best improvement in neurological dysfunction.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-11-02
• Status Verified: 2012-05
• Study First Submitted QC: 2012-05-07
• Study First Posted: 2012-05-08
• Last Update Submitted: 2012-05-08
• Last Update Posted: 2012-05-09
• Study Start: 2012-09
• Primary Completion: 2014-07
• Study Completion: 2014-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• patients admitted with acute ischemic stroke
• age > 18 years
• first stroke or only minor invalidity from previous strokes (mRS 0-2)
• truncal stability
• SSS < 58

Exclusion Criteria

• symptoms attributable to other diseases than ischemic stroke
• debut of symptoms > 48 h prior to admission
• consent not given < 24 h of admission
• pregnancy or lactation
• isolation
• blood sampling generally not possible
• allergy due to accelerometer wear
• ulcers or other skin diseases in the area of accelerometer placement
• unstable cardiologic condition (AMI etc.)
• acute high and sustained resting systolic blood pressure where treatment is necessary
• acute heart rhythm disorder where treatment is necessary
• unable to cooperate
• significant orthopedic conditions (fractures etc.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low Dose Training	physical activity 15 minutes/day	15 minutes/day on a weight-bearing treadmill
High Dose Training	physical activity, 2 x 30 minutes/day	2x 30 minutes/day on a weight-bearing treadmill

Primary Outcome Measures

Name	Time	Method
change in disability from baseline	up to 5 days	Scandinavian Stroke Scale (SSS)

Secondary Outcome Measures

Name	Time	Method
change in inflammation level from baseline	up to 5 days	biomarker concentration: Interleukin (IL)-6, IL-1beta, Tumor Nekrosis Factor(TNF)-alpha, C-Reactive Proteine (CRP), IL-1ra, IL-10, fasting-insuline, fasting-glucose
change in disability from baseline	up to 5 days	National Institutes of Health Stroke Scale score (NIHSS), Glasgow Coma Scale (GCS), Barthels Index-100 (BI), 10 Meters Walking Test (10MWT), modified Rankin Scale (mRS), Assessment of Motor and Process Skills (AMPS)
changes and level of activity during up to 5 days of hospitalization	up to 5 days	activity counts per day measured by an accelerometer
number of complications per patient	up to 30 days	all complications are counted from inclusion till day 30 in all patients

Trial Locations

Locations (1)

Hillerød Hospital; 🇩🇰 Hillerød, Denmark