Non-invasive Measurement of Cerebral Dynamic Autoregulation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Pennsylvania
- Enrollment
- 21
- Locations
- 2
- Primary Endpoint
- dCA Measurement During Acute Changes in Mean Arterial Pressure, Optical
Study Overview
Brief Summary
The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age greater than or equal to 50 years
- •Positive history of at least one of the following vascular disk factors: hypertension, diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior myocardial infarct, transient ischemic attack, or history of smoking
Exclusion Criteria
- •Vascular risk factor subjects:
- •Pregnant women
- •Prior neurosurgical procedure or traumatic brain injury, including hemicraniectomy or other skull defect
- •Prior history of ischemic or hemorrhagic stroke
- •Prior lower extremity amputation
- •Peripheral vascular disease
Outcomes
Primary Outcomes
dCA Measurement During Acute Changes in Mean Arterial Pressure, Optical
Time Frame: 1.5 hours
Rate of Regulation, measured using diffuse correlation spectroscopy. Rate of regulation (ROR) is calculated as follows: ROR = (change in relative cerebrovascular resistance / change in time) / maximum fractional decrease in blood pressure due to thigh cuff deflation.
dCA Measurement During Acute Changes in Mean Arterial Pressure, TCD
Time Frame: 1.5 hours
Rate of Regulation, measured using transcranial doppler. Rate of regulation (ROR) is calculated as follows: ROR = (change in relative cerebrovascular resistance / change in time) / maximum fractional decrease in blood pressure due to thigh cuff deflation.
Secondary Outcomes
No secondary outcomes reported