Non-invasive Measurement of Cerebral Dynamic Autoregulation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- dCA Measurement During Acute Changes in Mean Arterial Pressure, Optical
研究概览
简要总结
The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age greater than or equal to 50 years
- •Positive history of at least one of the following vascular disk factors: hypertension, diabetes, hyperlipidemia, coronary artery disease, atrial fibrillation, prior myocardial infarct, transient ischemic attack, or history of smoking
排除标准
- •Vascular risk factor subjects:
- •Pregnant women
- •Prior neurosurgical procedure or traumatic brain injury, including hemicraniectomy or other skull defect
- •Prior history of ischemic or hemorrhagic stroke
- •Prior lower extremity amputation
- •Peripheral vascular disease
研究组 & 干预措施
Intervention
We will measure dCA with both TCD and DCS during acute changes in mean arterial pressure using thigh cuff deflation techniques in vascular risk factor subjects. Measurements will be compared between TCD and DCS in order to validate DCS as a tool to measure dCA in this population.
干预措施: Thigh Cuff (Device)
结局指标
主要结局
dCA Measurement During Acute Changes in Mean Arterial Pressure, Optical
时间窗: 1.5 hours
Rate of Regulation, measured using diffuse correlation spectroscopy. Rate of regulation (ROR) is calculated as follows: ROR = (change in relative cerebrovascular resistance / change in time) / maximum fractional decrease in blood pressure due to thigh cuff deflation.
dCA Measurement During Acute Changes in Mean Arterial Pressure, TCD
时间窗: 1.5 hours
Rate of Regulation, measured using transcranial doppler. Rate of regulation (ROR) is calculated as follows: ROR = (change in relative cerebrovascular resistance / change in time) / maximum fractional decrease in blood pressure due to thigh cuff deflation.
次要结局
未报告次要终点