ACTRN12612000271808已完成4 期
Hemostatic effects of levothyroxine and selenomethionine in euthyroid women with Hashimoto's thyroiditis: a six-month single-center, randomized, double-blind, placebo-controlled study
the Polish Committee of Scientific Research0 个研究点目标入组 155 人开始时间: 2012年3月7日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 155
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 18 Years 至 65 Years（—）
- 性别
- Female
入选标准
- •(a) positive antibodies (>100 U/mL) against thyroid peroxidase (TPOAb), (b) the reduced echogenicity of the thyroid parenchyma on thyroid ultrasonography, (c) serum TSH less than 4.0 mU/L, and (d) plasma levels of free thyroxine (fT4) and free triiodothyronine (fT3)) within the reference range
排除标准
- •A) any acute and chronic inflammatory processes
- •B) other autoimmune disorders
- •C) positive serum antibodies against TSH receptor
- •D) current treatment with thyroid hormones
- •E) concomitant treatment with drugs that may affect inflammatory processes in the vascular wall
- •F) concomitant treatment with other drugs known either to affect thyroid hormones or to interact with levothyroxine and selenomethionine
- •G) BMI>40 kg/m2
- •H) Turner or Down syndrome
- •I) any form of coronary artery disease
- •J) moderate or severe arterial hypertension (ESC/ESH grade 2 or 3)
- •K) symptomatic congestive heart failure
- •L) diabetes, impaired glucose tolerance or impaired fasting glucose
- •M) impaired renal or hepatic function
- •N) pregnancy or lactation
- •O) poor patient compliance
研究者
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