Double-blind, randomised, placebo-controlled study to investigate the efficacy of nasal spray and mouth wash containing hypochlorous acid in SARS-CoV-2 infected patients
Not Applicable
Recruiting
- Conditions
- U07.1COVID-19, virus identified
- Registration Number
- DRKS00030721
- Lead Sponsor
- Technische Universität DresdenInstitut für Klinische Pharmakologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Persons = 18 years old, capable to give informed consent
- Infected with SARS-CoV-2, confirmed with antigen or PCR test
- First positive test or symptom onset were not more than 72 h ago
Exclusion Criteria
- Recent (during the last 4 weeks before inclusion in the study) or regular use of HOCl containing or other products for disinfection of oral or nasal mucosa (e.g. chlorhexidine)
- Use of nasal medicines during the study
- Antiviral therapy (e.g. Paxlovid)
- Known or suspected hypersensitivity against ingredients of the test product or placebo
- Pregnancy, breast feeding
- Hospitalization due to COVID-19 symptoms
- Cognitive impairment
- Oxygen therapy, inhalative therapy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method • ercentage of patients with increase of symptoms between days 3 and 10 (questionnaire)<br>• Days until continuously negative antigen test
- Secondary Outcome Measures
Name Time Method • Decrease of viral load between day 0 / 1 and day 4-6 (quantitative PCR)