Comparison of efficacy of 5% calcium sodium phosphosilicate and 8% arginine and calcium carbonate in reducing dentin hypersensitivity following non-surgical periodontal therapy

Phase 2

Completed

• Conditions: Dentin hypersensitivityChronic periodontitis; Dentin hypersensitivity; Root sensitivity; Arginine and calcium carbonate; Desensitizing agent; Calcium sodium phosphosilicate

• Registration Number: TCTR20180611003
• Lead Sponsor: Faculty of Dentistry, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-06-11
• Study Completion: 2020-01-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

The inclusion and exclusion criteria are modified from the guidelines for the design and conduct of clinical trials on dentine hypersensitivity (Holland et al. 1997)
1.Adults between 30-65 years of age
2.Individual diagnosed with chronic periodontitis
3.Compliant about at least 2 teeth with DH after receiving at least one visit of scaling and root planing and diagnosed by dentist with air blast (Schiff’s score 2-3) or tactile stimulation (VAS sensitivity score more than 4, moderate to severe DH)
4.Good general health

Exclusion Criteria

1.Symptom of DH prior to periodontal treatment
2.Using agents to treat hypersensitivity in the past 3 months
3.Pharmacotherapeutic histories that may compromise the protocol including the chronic use of anti-inflammatory, analgesic and mind-altering drugs
4.Allergy to either 5% calcium sodium phosphosilicate or 8% arginine and calcium carbonate
5.DH from dental caries, defective restoration, fractured tooth
6.Extensively restored teeth and those with restorations extending into the test area
7.Orthodontic appliance treatment within previous 3 months
8.Crowded teeth
9.Abutment teeth for fixed or removable prostheses

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Schiff Cold Air Sensitivity Scale baseline, immediately after in-office apply desensitizing toothpaste, 1, 2 , 4, and 8 weeks A blast of air from a dental syringe will be applied. The investigator will assess patient response.

Secondary Outcome Measures

Name	Time	Method
VAS sensitivity score baseline, immediately after in-office apply desensitizing toothpaste, 1, 2 , 4, and 8 weeks The examiner will move the explorer in mesiodistal direction on the area of exposed dentin and ask t,Overall VAS sensitivity score in daily life baseline, 1, 2 , 4, and 8 weeks Patient reported outcome using a questionnaire interview