Calcium Retention as Influenced by Dietary Components That Induce an Acid Load

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: High Meat - High Potential Renal Acid Load (PRAL) diet; Other: Low Protein - Low Potential Renal Acid Load (PRAL) diet

• Registration Number: NCT00620763
• Lead Sponsor: USDA Grand Forks Human Nutrition Research Center

Brief Summary

The impact of protein sources such as beef as part of Western diet on calcium retention remains controversial. We propose to test the hypothesis that the positive effect of high protein intake (especially from meat protein) can offset the negative effect of protein-induced net acid load on bone metabolism and the retention of body calcium. Healthy postmenopausal women recruited from the community will consume two diets differing in meat protein and acid load for 7 weeks. Calcium retention from diets will be determined using a highly sensitive measurement of whole body retention of a calcium isotope added to the diet.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-01
• Study First Submitted: 2008-01-18
• Study First Submitted QC: 2008-02-08
• Study First Posted: 2008-02-21
• Primary Completion: 2008-05
• Study Completion: 2008-05
• Results First Submitted: 2008-12-31
• Results First Submitted QC: 2009-06-17
• Results First Posted: 2009-08-03
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-24
• Last Update Posted: 2018-07-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 22

Inclusion Criteria

• Average body mass index
• Normal blood work
• Normal bone density

Exclusion Criteria

• Chronic disorder
• Non-traumatic bone fractures

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
B	Low Protein - Low Potential Renal Acid Load (PRAL) diet	Dietary Intervention: Low meat and low acid load diet followed by high meat and high acid load diet
A	High Meat - High Potential Renal Acid Load (PRAL) diet	Dietary Intervention: High meat and high acid load diet followed by low meat and low acid load diet
A	Low Protein - Low Potential Renal Acid Load (PRAL) diet	Dietary Intervention: High meat and high acid load diet followed by low meat and low acid load diet
B	High Meat - High Potential Renal Acid Load (PRAL) diet	Dietary Intervention: Low meat and low acid load diet followed by high meat and high acid load diet

Primary Outcome Measures

Name	Time	Method
Calcium Absorption	18 weeks	After 3 weeks equilibration to the diet, the 2-day menu was extrinsically labeled with Calcium-47 radiotracer and retention was monitored for 28 days by whole body scintillation counting. Percent Calcium-47 absorbed was estimated from the y-intercept of the linear portion of a semilogarithmic plot of percent Calcium-47 retained vs time.

Trial Locations

Locations (1)

United States Department of Agriculture (USDA) Grand Forks Human Nutrition Research Center; 🇺🇸 Grand Forks, North Dakota, United States