Annual MRI Versus Biannual US for Surveillance of Hepatocellular Carcinoma in Liver Cirrhosis

Not Applicable

Recruiting

• Conditions: Diseases of the digestive system

• Registration Number: KCT0001739
• Lead Sponsor: The Catholic University of Korea

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 211

Inclusion Criteria

Male or female subject between 20 and 70 years of age at the enrollment
Has chronic liver disease
Fulfill below conditions A and B

A.The evidence of cirrhosis of any etiology within 12 months prior to screening Definition of cirrhosis by any of following methods
1) Histologically by liver biopsy;
2) Non-histologically by evidence of portal hypertension in the presence of chronic liver disease;
- Evidence of portal hypertension, including any of followings;
>The identification of splenomegaly on ultrasonography, CT, or MRI examinations with typical features of cirrhosis
>The identification of esophageal or gastric varices on endoscopic examination

B. Risk Index more than 2.33 ; Risk Index = 1.65 (if PT% is <=75%) + 1.41 (if the age is 50 years or older) + 0.92 (if the platelet count is <=100x10(3)/mm3) + 0.74 (if the presence of HCV is positive).

Exclusion Criteria

Presence of liver cancer or other malignancy
No liver cirrhosis
pregnant or breast-feeding

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sensitivity

Secondary Outcome Measures

Name	Time	Method
False referral rate