HEmiplegia Arrhythmia Retrospective Trial
- Conditions
- Alternating Hemiplegia of Childhood
- Registration Number
- NCT04944927
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Alternating Hemiplegia of Childhood (AHC) is a rare and severe disease that is in need of effective, and hopefully even curative, therapies. Afflicted patients suffer from severe paralyzing crises, often excruciatingly painful muscle spasms, severe often life threatening epileptic seizures, frequently severe developmental and psychiatric/psychological disabilities and other comorbidities, such as cardiac disturbances. Recent data indicate that AHC genotype is in relation to cardiac repolarization troubles and to cardiac arrhythmias. The primary hypothesis to explore is that there is an association between genotype and cardiac phenotype in AHC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Patients that meet the clinical diagnostic criteria (Aicardi et al, 1995) for typical alternating hemiplegia with or without identified mutations in ATP1A3.
- At least one ECG study is required.
- Patients ages yearand more
- Informed consent or assent not obtainable
- ATP1A3 testing not performed
- No ECG studies are available
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of QTc interval and all relevant cardiac repolarization measurements Day 1 Outcome measure: QTc interval and cardiac repolarization measurement in milliseconds.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Clinical Epileptology, Sleep Disorders and Functional Neurology in Children, Hôpital Femme Mère Enfant, University Hospitals of Lyon (Hospices Civils de Lyon)
🇫🇷Bron, France
Department of Clinical Epileptology, Sleep Disorders and Functional Neurology in Children, Hôpital Femme Mère Enfant, University Hospitals of Lyon (Hospices Civils de Lyon)🇫🇷Bron, France