Effect of Anthocyanins Extracted From Purple Potatoes on Healthy Study Subjects' Postprandial Glycemia and Insulinemia

University of Turku1 site in 1 country18 target enrollmentOctober 2016

ConditionsPostprandial Glycemia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Postprandial Glycemia
Sponsor: University of Turku
Enrollment: 18
Locations: 1
Primary Endpoint: Plasma glucose concentration
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

A randomized, single-blind cross-over clinical nutrition trial will be conducted. The effects of yellow-fleshed potatoes and yellow-fleshed potatoes supplemented with anthocyanins extracted from purple-fleshed potatoes on healthy men's postprandial glycemia and insulinemia will be compared. Additionally, the postprandial metabolism and metabolites, and the appearance and metabolism of the flavonoids and their metabolites is studied in plasma, urine and feces.

Registry

clinicaltrials.gov

Start Date

October 2016

End Date

December 31, 2021

Last Updated

4 years ago

Study Type

Interventional

Study Design

Crossover

Sex

Male

Investigators

Sponsor

University of Turku

Responsible Party

Principal Investigator

Kaisa Linderborg

Principal Investigator

University of Turku

Eligibility Criteria

Inclusion Criteria

•Age 18-45
•No regular medication
•No participation in a drug trial or blood donation within 2 months
•Non-smoker
•Signs informed consent
•Body mass index 18.5-27 kg/m2
•Fasting plasma cholesterol \< 5.5 mmol/l
•Fasting plasma triacylglycerols \< 2.6 mmol/l
•Fasting plasma glucose 4-6 mmol/l
•blood pressure \<140/80 mmHg

Exclusion Criteria

•Regular smoking
•Alcohol abuse
•Regular medication

Outcomes

Primary Outcomes

Plasma glucose concentration

Time Frame: 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

Plasma insulin concentration

Time Frame: 0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min

Secondary Outcomes

Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in plasma (NMR and (U)HPLC-MS/MS measurements)(0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min)
Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in urine (NMR and (U)HPLC-MS/MS measurements)(Before meal, and 0-4h, 4-8h, 8-16h, 16-24 h)
Concentrations and quality of metabolites and flavonoid color compounds and their metabolites in feces (NMR and (U)HPLC-MS/MS measurements)(before and after meal)
Area under the glucose concentration curve (AUC)(0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min)
Area under the insulin concentration curve (AUC)(0min, 20min, 40min, 60min, 90min, 120min, 180min, 240min)