Post-intensive Care Follow-up of Patients Hospitalized for an Acute Respiratory Distress Syndrome (ARDS) Caused by SARS-CoV-2 (COVID-19)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Human ARDS
- Sponsor
- University Hospital, Toulouse
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Incidence of Post-traumatic Stress Disorder (PTSD) with the Post-traumatic Checklist-5 (PCL-5) 12 months after intensive-care
- Last Updated
- 3 years ago
Overview
Brief Summary
For the last years, studies have described the " Post-intensive care Syndrome " (PICS), which consists in alteration of quality of life, cognition, autonomy and psychological disorders within the months after intensive-care. Patients with COVID-19 in intensive care units are at high risks to develop PICS.
The primary objective is to analyse the incidence of the post-traumatic stress disorder at 12 months after intensive-care for a COVID-19 Acute Respiratory Distress Syndrome (ARDS).
Detailed Description
Many studies have showed that ARDS survivors keep, even a long time after hospitalization, a functional respiratory disability, resulting on one hand from impaired diffusion of carbon monoxide, and on the other hand from a muscular weakness. Indeed, 67% of patients ventilated more than 10 days have a neuromyopathy whose recovery is uncertain. Beside this, Long-term quality of life is worse than in general population, due in particular to depressive and anxiety disorders such as post-traumatic syndrome disorder with a prevalence around 22% after one year. The follow-up will consist in phone call with an intensive care doctor. These visits would be the opportunity to screen the complications after intensive-care with, find solutions to cure them or decrease their impact on patient's life to improve quality of life and prevent the post-traumatic syndrome disorder PTSD. A review would be sent to the patients' General Practitioners at the end of each visit.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adult patient
- •hospitalized in intensive care of the CHU anesthesia-intensive care unit (Rangueil, URM, Neurosurgery)
- •intubated and ventilated
- •supported for an ARDS according to the Berlin criteria (PaO2 / FiO2 ratio \<300 mmHg)
- •with an rt-PCR positive to SARS-CoV-2
- •affiliated to the french social security
Exclusion Criteria
- •minor patient
- •patient under protective measure
- •ARDS in the pandemic context but rt-PCR negative to SARS-CoV-2
Outcomes
Primary Outcomes
Incidence of Post-traumatic Stress Disorder (PTSD) with the Post-traumatic Checklist-5 (PCL-5) 12 months after intensive-care
Time Frame: month 12
Incidence of Post-traumatic Stress Disorder (PTSD) with the Post-traumatic Checklist-5 (PCL-5) 12 months after intensive-care
Secondary Outcomes
- psychological disorders measured by STAI-YA(Month 12)
- nutritional status(Month 12)
- psychological disorders measured by QIDS(Month 12)
- quality of life by EQL-5(Month 12)