Generation 100: Blood Volume and Cardiac Function in Healthy Aging

Not Applicable

Completed

• Conditions: Ageing
• Interventions: Behavioral: high intensity interval training; Behavioral: moderate intensity training

• Registration Number: NCT01765816
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2013-01-08
• Study First Submitted QC: 2013-01-08
• Study First Posted: 2013-01-10
• Primary Completion: 2014-02
• Study Completion: 2014-11
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-25
• Last Update Posted: 2020-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• ability to walk at least 1km,
• born in 1938,1939,1940,1941 or 1942
• Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion Criteria

• Illness or disability that precludes exercise or hinders completion of the study
• Uncontrolled hypertension
• Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina
• Active cancer
• Test results indicating that study participation is unsafe
• Inclusion in other studies conflicting with participation in this one

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
high intensity interval training	high intensity interval training	one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate
high intensity interval training	moderate intensity training	one interval training session with 1 x 4 and 4 x 4 minutes interval training at 90-95% of peak heart rate
moderate intensity training	moderate intensity training	45 minutes of moderate continuous training at 75% of maximal heart rate
moderate intensity training	high intensity interval training	45 minutes of moderate continuous training at 75% of maximal heart rate

Primary Outcome Measures

Name	Time	Method
total blood volume	24 hours	carbon monoxide-rebreathing spirometry (Bayreuth, Germany)

Secondary Outcome Measures

Name	Time	Method
hemoglobin volume	24 hours	carbon monoxide-rebreathing spirometry (Bayreuth, Germany)

Trial Locations

Locations (1)

Norwegian University of Science and Technology; 🇳🇴 Trondheim, Norway