Evaluation of mortality and morbidity outcome in patients with septic shock due to intra-abdominal sepsis using Alteco Lipopolysaccharide adsorption technique

Not Applicable

• Conditions: Patients with septic shock due to intra-abdominal sepsis required vasopressor support; Infection - Other infectious diseases

• Registration Number: ACTRN12610000892011
• Lead Sponsor: Department of intensive care, Pamela Youde Nethersole Eastern Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-10-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1.Septic shock (definition based on ACCP/ SCCM criteria) due to intra-abdominal sepsis and,
2.Require vasopressor support (single strength noradrenaline >=10ml/h), and
3.On steroid (hydrocortisone 200-300mg/d or equivalent)

Exclusion Criteria

1.Contraindication for heparin/ low molecular heparin use (hypersensitivity to heparin/ LMWH or any component of the formulation; known history of heparin induced thrombocytopenia; severe thrombocytopenia (<50,000 / mm3); uncontrolled active bleeding except when due to disseminated intravascular coagulation)
2.Pregnancy
3.Terminal illness

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sequential Organ Failure Assessment (SOFA) score changes <br>Tool used for assessment: SOFA score[0, 1, 2, 4, 8, 12, 16, 20, 24, 32, 40, 48, 56, 64 and 72 hrs following randomization];Mean arterial pressure (MAP) <br>Tool used for assessment: Invasive continuous arterial blood pressure monitoring[0, 1, 2, 4, 8, 12, 16, 20, 24, 32, 40, 48, 56, 64 and 72 hrs following randomization];Vasopressor (Noradrenaline/ adrenaline) dosage<br>Tool used for assessment: Patient's electronic medication record on use of vasopressor[0, 1, 2, 4, 8, 12, 16, 20, 24, 32, 40, 48, 56, 64 and 72 hrs following randomization]