Can Tea Prevent Impairments in Vascular Function and Insulin Sensitivity Induced by 7-days Physical Inactivity and Overfeeding in Healthy Men
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Insulin sensitivity
Study Overview
Brief Summary
The aim of this research is to explore changes in peripheral/cerebrovascular function and insulin sensitivity after a 7-day combination of physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) in healthy male volunteers, and examine whether daily intake of tea can prevent such changes.
Detailed Description
The aim of this study is to explore the impact of a 7-day 'unhealthy' lifestyle that combines physical activity reduction (-50% steps per day) and overfeeding (+50% kcal per day, comprising 65% fat) on peripheral (conduit artery and skin microvessels) and cerebrovascular function and insulin sensitivity in healthy male participants. Moreover, the investigators will explore whether the detrimental impact of this lifestyle can be mitigated by daily tea consumption (equivalent to 6 cups/day). To explore this hypothesis, the investigators will perform measurements of these parameters before and after 7-days of reduced physical activity and overfeeding, with and without the combination of daily tea ingestion.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Aged 18-55 years
- •Habitually active (>8,000 steps/day)
Exclusion Criteria
- •Medical history of cardiovascular/metabolic disease
- •Family history of cardiovascular disease (first degree relatives)
- •On medication known to influence the cardiovascular system
- •BMI of <18 or >30 kg/m2
- •Known food allergies or special dietary requirements
- •Vaccination (<1 week) due to induced systemic inflammatory reaction
Arms & Interventions
Placebo tea
Tea to be ingested 3 times per day for 7 days.
Intervention: Placebo tea (Dietary Supplement)
Active (green) tea
Tea to be ingested 3 times per day for 7 days.
Intervention: Green tea (Dietary Supplement)
Outcomes
Primary Outcomes
Insulin sensitivity
Time Frame: Post 7 day intervention
This will be measured following a carbohydrate-rich meal tolerance test (MTT) after an overnight fast, combined with regular venous blood sampling of insulin and glucose.
Secondary Outcomes
- Vascular function(Post 7 day intervention)
Investigators
Kirsty Woodward
PhD Student
Liverpool John Moores University