Oral Misoprostol Before Endometrial Biopsy
- Registration Number
- NCT00200226
- Lead Sponsor
- Memorial University of Newfoundland
- Brief Summary
An endometrial biopsy involves a thin tube being passed through the cervix (opening of the uterus) to obtain a sample of the lining of the uterus. Sometimes there may be discomfort with this procedure especially if the cervix is not dilated or opened. Previous research has suggested that taking a drug called misoprostol may help the cervix to start to dilate or open. This study will see if misoprostol will help open the cervix for an endometrial biopsy, to lessen the discomfort and make the biopsy easier to perform.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 72
Inclusion Criteria
- women 19 years and older
- planned endometrial biopsy
Exclusion Criteria
- known hypersensitivity or allery to prostaglandins
- seizure disorder
- liver disease
- known abnormal liver function tests
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 2 misoprostol misoprostol 1 vitamin B6 Vitamin B6
- Primary Outcome Measures
Name Time Method pain/discomfort of endometrial biopsy during procedure
- Secondary Outcome Measures
Name Time Method ease of performing biopsy during procedure success of obtaining biopsy during procedure potential side effects time study drug taken until procedure
Trial Locations
- Locations (2)
Women's Health Centre, Eastern Health
🇨🇦St. John's, Newfoundland and Labrador, Canada
Obstetrics and Gynecology Associates
🇨🇦Dartmouth, Nova Scotia, Canada